| 54 |
Titel |
TI |
[EN] Pharmaceutical compositions containing mesembrine and related compounds |
| 71/73 |
Anmelder/Inhaber |
PA |
PHARMA NATURA PTY LTD, ZA
|
| 72 |
Erfinder |
IN |
GERICKE NIGEL PETER, ZA
;
VAN WYK BEN-ERIK, ZA
|
| 22/96 |
Anmeldedatum |
AD |
22.03.1999 |
| 21 |
Anmeldenummer |
AN |
19483699 |
|
Anmeldeland |
AC |
US |
|
Veröffentlichungsdatum |
PUB |
11.09.2001 |
33
31
32 |
Priorität |
PRC
PRN
PRD |
GB
9701493
19970603
|
33
31
32 |
PRC
PRN
PRD |
ZA
964595
19960604
|
| 51 |
IPC-Hauptklasse |
ICM |
A61K 31/40
|
| 51 |
IPC-Nebenklasse |
ICS |
|
|
IPC-Zusatzklasse |
ICA |
|
|
IPC-Indexklasse |
ICI |
|
|
Gemeinsame Patentklassifikation |
CPC |
A61K 31/404
A61P 3/04
C07D 209/32
C07D 209/08
A61P 25/32
A61P 43/00
A61P 25/04
A61P 25/22
A61P 25/20
A61P 25/24
A61P 3/00
|
|
MCD-Hauptklasse |
MCM |
C07D 209/12
(2006.01)
|
|
MCD-Nebenklasse |
MCS |
A61K
(2006.01)
A61K 31/00
(2006.01)
A61K 31/40
(2006.01)
A61K 31/403
(2006.01)
A61K 31/404
(2006.01)
C07D 209/32
(2006.01)
A61P 3/04
(2006.01)
A61P 25/04
(2006.01)
A61P 43/00
(2006.01)
C07D
(2006.01)
C07D 209/08
(2006.01)
A61P 3/00
(2006.01)
|
|
MCD-Zusatzklasse |
MCA |
|
| 57 |
Zusammenfassung |
AB |
[EN] There is disclosed the use of mesembrine and related compounds (e.g. mesembranol, mesembranone) as scrotonin-uptake inhibitors, pharmaceutical compositions comprising such compounds or dry material or an extract of plants from the Mesembryanthemaceae family (e.g. Sceletium (Aizoaceae) tortuosum) containing a standardized content of said compounds, for use in the treatment of depressive states, psychological or psychiatric disorders with an anxiety component, alcohol and drug dependence, bulimia nervosa and obsessive-compulsive disorders. Also disclosed are new derivatives of mesembrine. |
|
Korrekturinformation |
KORRINF |
|
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt |
CT |
|
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt |
CT |
JP000046043538A
JP000046043539A
DE000003604112A1 
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt |
CTNP |
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt |
CTNP |
Capps et al., "Sceletium Alkaloids, Part 7.1 Structure and Absolute Stereochemistry of (-)-Mesembrane and 3'-Methoxy-4'-O-methyljoubertiamine, Two Minor Bases from S. Namaquense L. Bolus: X-Ray Analysis of (-)-Mesembrane Hydrochloride Monohydrate," J. Chem. Soc. Perkins Trans. 8:1098-1104 (1977). 1;
Hoshino et al., "Synthesis of Sceletium and Amaryllidaceae Alkaloids, (±)-Mesembrine and (±)-Dihydromaritidine, (±)Epidihydromaritidine, (±-Elwesine, and (±)-Epielwesine1)," Chem. Pharm. Bull. 35:2734-2743 (1987). 1;
Jeffs et al., "Sceletium Alkaloids. VI. Minor Alkaloids of S. namaquense and S. strictum," J. Org. Chem. 39:2703-2710 (1974). 1;
Jeffs et al., "Total Syntheses of (±)-Joubertinamine, and (±)-N-Demethylmesembrenone," J. Org. Chem. 48:3861-3863 (1983). 1;
Kruger et al., "Minor Alkaloids from Sceletium Strictum L. Bol. The Structure of N-Demethylmesembrenol and N-Demthylmesembranol," Journal of the South African Chemical Institute XXIV:235-237 (1971). 1;
Langlois et al., "Recherches Dans La Serie Des Aryl-3 Pyrrolidines-II, Syntheses de Produits Apparentes a la Mesembrine et a La Crinine," Tetrahedron 27:5641-5652 (1971). 1;
Pfaffli et al., "Demethylierungen am Mesembrine," Helvetica Chimica Acta 56:347-355 (1973). 1;
Smith et al., "Psychoactive constituents of the genus Sceletium N.E.Br. and otehr Mesembryanthemaceae: a review," Journal of Ethnopharmacology 50:119-130 (1996). 1;
Taguchi et al., "Synthesis of Octahydroindole Derivatives," Tetrahedrom Letters, 55:5763-5766 (1968). 1;
Taguchi et al., "Synthesis of Octhydroindole Derivatives," Chem. Pharm. Bull. 18:1008-1014 (1970). 1
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