| 54 |
Title |
TI |
[EN] CHEMO-ENZYMATIC PREPARATION METHOD FOR PURINE NUCLEOSIDES AND THEIR DEAZA- AND AZA- ANALOGUES
[FR] PROCÉDÉ CHIMIO-ENZYMATIQUE POUR LA PRÉPARATION DE NUCLÉOSIDES DE PURINE ET LEURS ANALOGUES DÉAZA ET AZA |
| 71/73 |
Applicant/owner |
PA |
UNIV BERLIN TECH, DE
|
| 72 |
Inventor |
IN |
MIKHAILOPULO IGOR, BY
;
NEUBAUER PETER, DE
;
ZHOU XINRUI, DE
|
| 22/96 |
Application date |
AD |
Sep 7, 2015 |
| 21 |
Application number |
AN |
2015070334 |
|
Country of application |
AC |
EP |
|
Publication date |
PUB |
Mar 10, 2016 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
EP
14183836
20140905
|
| 51 |
IPC main class |
ICM |
C07H 19/06
(2006.01)
|
| 51 |
IPC secondary class |
ICS |
C07H 1/00
(2006.01)
C07H 19/16
(2006.01)
C12N 9/10
(2006.01)
C12P 19/38
(2006.01)
|
|
IPC additional class |
ICA |
|
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IPC index class |
ICI |
|
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Cooperative patent classification |
CPC |
C07H 1/00
C07H 19/06
C07H 19/16
C12P 19/40
|
|
MCD main class |
MCM |
C07H 19/06
(2006.01)
|
|
MCD secondary class |
MCS |
C07H 1/00
(2006.01)
C07H 19/16
(2006.01)
C12N 9/10
(2006.01)
C12P 19/38
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[EN] The present invention relates to a new, chemo-enzymatic preparation method of purine nucleosides and their deaza- and aza analogues of general formula I or pharmaceutically acceptable esters or salts thereof (I) wherein X, Y, Z and V independently from each other represent a nitrogen or carbon atom, W represents a nitrogen atom, -CH, -CF or –C-NH2, R1 represents hydrogen, fluorine (ribo/arabino), -OH (ribo/arabino) or -NH2 (ribo), R 2 represents -OH, -NH 2 or hydrogen,and Sub 2 and Sub 6 represent hydrogen, chlorine, fluorine, bromine or -NH 2, wherein at least one of Sub 2 and Sub 6 is -NH2.
[FR] La présente invention concerne un nouveau procédé chimio-enzymatique pour la préparation de nucléosides de purine et de leurs analogues déaza et aza de formule générale (I) ou leurs esters ou leurs sels pharmaceutiquement acceptables. Dans la formule (I), X, Y, Z et V représentent, indépendamment les uns des autres, un atome d'azote ou de carbone, W représente un atome d'azote, -CH,-CF ou-C-NH2, R1 représente un atome d'hydrogène, de fluor (ribo/arabino), -OH (ribo/arabino) ou-NH2 (ribo), R2 représente-OH,-NH2 ou un atome d'hydrogène, et Sub2 et Sub6 représentent un atome d'hydrogène, un atome de chlore, un atome de fluor, un atome de brome ou -NH2, l'un au moins parmi Sub2 et Sub6 étant -NH2. |
| 56 |
Cited documents identified in the search |
CT |
|
| 56 |
Cited documents indicated by the applicant |
CT |
EP000000173059A2
EP000001932918A1
WO002006013396A2
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
ALEX R. PAGANO ET AL: "Syntheses of [6,7-15N]-Adenosine, [6,7-15N]-2'-Deoxyadenosine, and [7-15N]-Hypoxanthine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 117, no. 47, 1 November 1995 (1995-11-01), US, pages 11669 - 11672, XP055220155, ISSN: 0002-7863, DOI: 10.1021/ja00152a006 7;
GEORGE UOSWORTH BROWN ET AL: "THE SYNTHESIS OF 9-P-n-RIBOFURANOSYLPURINE AND THE IDENTITY OF NEBULARINE*", 13 March 1953 (1953-03-13), XP055220191, Retrieved from the Internet 7;
KATHLEEN SZEKER: "Nucleoside phosphorylases from thermophiles Recombinant expression and biocatalytic use for modified nucleosides", DOCTORAL THESIS, 24 September 2012 (2012-09-24), XP055175937, Retrieved from the Internet [retrieved on 20150312] 7;
SZEKER KATHLEEN ET AL: "Comparative investigations on thermostable pyrimidine nucleoside phosphorylases fromGeobacillus thermoglucosidasiusandThermus thermophilus", JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC, vol. 84, 25 February 2012 (2012-02-25), pages 27 - 34, XP028939170, ISSN: 1381-1177, DOI: 10.1016/J.MOLCATB.2012.02.006 7;
XINRUI ZHOU ET AL: "Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides", FEBS JOURNAL, vol. 280, no. 6, 21 March 2013 (2013-03-21), pages 1475 - 1490, XP055175902, ISSN: 1742-464X, DOI: 10.1111/febs.12143 7;
XINRUI ZHOU: "Thermostable Nucleoside Phosphorylases as Biocatalysts for the Synthesis of Purine Nucleoside Analogues Characterisation, immobilization and synthesis", DOCTORAL THESIS, 30 April 2014 (2014-04-30), XP055175917, Retrieved from the Internet [retrieved on 20150312] 7
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
T. ROBAK ET AL., CURR. PHARM. DES., vol. 18, 2012, pages 3373 - 3388 1;
VLADIMIR N. BARAI ET AL., HELVETICA CHIMICA ACTA, vol. 85, 2002, pages 1901 - 1908 1
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Citing documents |
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Determine documents
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Sequence listings |
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Search file IPC |
ICP |
C07H 1/00
C07H 19/06
C07H 19/16
C12N 9/10
C12P 19/38
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