| 54 |
Titel |
TI |
[EN] CHEMO-ENZYMATIC PREPARATION METHOD FOR PURINE NUCLEOSIDES AND THEIR DEAZA- AND AZA- ANALOGUES
[FR] PROCÉDÉ CHIMIO-ENZYMATIQUE POUR LA PRÉPARATION DE NUCLÉOSIDES DE PURINE ET LEURS ANALOGUES DÉAZA ET AZA |
| 71/73 |
Anmelder/Inhaber |
PA |
TECH UNIVERSITÄT BERLIN, DE
|
| 72 |
Erfinder |
IN |
MIKHAILOPULO IGOR, BY
;
NEUBAUER PETER, DE
;
ZHOU XINRUI, DE
|
| 22/96 |
Anmeldedatum |
AD |
07.09.2015 |
| 21 |
Anmeldenummer |
AN |
2015070334 |
|
Anmeldeland |
AC |
EP |
|
Veröffentlichungsdatum |
PUB |
10.03.2016 |
33
31
32 |
Priorität |
PRC
PRN
PRD |
EP
14183836
20140905
|
| 51 |
IPC-Hauptklasse |
ICM |
C07H 19/06
(2006.01)
|
| 51 |
IPC-Nebenklasse |
ICS |
C07H 1/00
(2006.01)
C07H 19/16
(2006.01)
C12N 9/10
(2006.01)
C12P 19/38
(2006.01)
|
|
IPC-Zusatzklasse |
ICA |
|
|
IPC-Indexklasse |
ICI |
|
|
Gemeinsame Patentklassifikation |
CPC |
C07H 1/00
C07H 19/06
C07H 19/16
C12P 19/40
|
|
MCD-Hauptklasse |
MCM |
C07H 19/06
(2006.01)
|
|
MCD-Nebenklasse |
MCS |
C07H 1/00
(2006.01)
C07H 19/16
(2006.01)
C12N 9/10
(2006.01)
C12P 19/38
(2006.01)
|
|
MCD-Zusatzklasse |
MCA |
|
| 57 |
Zusammenfassung |
AB |
[EN] The present invention relates to a new, chemo-enzymatic preparation method of purine nucleosides and their deaza- and aza analogues of general formula I or pharmaceutically acceptable esters or salts thereof (I) wherein X, Y, Z and V independently from each other represent a nitrogen or carbon atom, W represents a nitrogen atom, -CH, -CF or –C-NH2, R1 represents hydrogen, fluorine (ribo/arabino), -OH (ribo/arabino) or -NH2 (ribo), R 2 represents -OH, -NH 2 or hydrogen,and Sub 2 and Sub 6 represent hydrogen, chlorine, fluorine, bromine or -NH 2, wherein at least one of Sub 2 and Sub 6 is -NH2.
[FR] La présente invention concerne un nouveau procédé chimio-enzymatique pour la préparation de nucléosides de purine et de leurs analogues déaza et aza de formule générale (I) ou leurs esters ou leurs sels pharmaceutiquement acceptables. Dans la formule (I), X, Y, Z et V représentent, indépendamment les uns des autres, un atome d'azote ou de carbone, W représente un atome d'azote, -CH,-CF ou-C-NH2, R1 représente un atome d'hydrogène, de fluor (ribo/arabino), -OH (ribo/arabino) ou-NH2 (ribo), R2 représente-OH,-NH2 ou un atome d'hydrogène, et Sub2 et Sub6 représentent un atome d'hydrogène, un atome de chlore, un atome de fluor, un atome de brome ou -NH2, l'un au moins parmi Sub2 et Sub6 étant -NH2. |
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt |
CT |
|
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt |
CT |
EP000000173059A2
EP000001932918A1
WO002006013396A2
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt |
CTNP |
ALEX R. PAGANO ET AL: "Syntheses of [6,7-15N]-Adenosine, [6,7-15N]-2'-Deoxyadenosine, and [7-15N]-Hypoxanthine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 117, no. 47, 1 November 1995 (1995-11-01), US, pages 11669 - 11672, XP055220155, ISSN: 0002-7863, DOI: 10.1021/ja00152a006 7;
GEORGE UOSWORTH BROWN ET AL: "THE SYNTHESIS OF 9-P-n-RIBOFURANOSYLPURINE AND THE IDENTITY OF NEBULARINE*", 13 March 1953 (1953-03-13), XP055220191, Retrieved from the Internet 7;
KATHLEEN SZEKER: "Nucleoside phosphorylases from thermophiles Recombinant expression and biocatalytic use for modified nucleosides", DOCTORAL THESIS, 24 September 2012 (2012-09-24), XP055175937, Retrieved from the Internet [retrieved on 20150312] 7;
SZEKER KATHLEEN ET AL: "Comparative investigations on thermostable pyrimidine nucleoside phosphorylases fromGeobacillus thermoglucosidasiusandThermus thermophilus", JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC, vol. 84, 25 February 2012 (2012-02-25), pages 27 - 34, XP028939170, ISSN: 1381-1177, DOI: 10.1016/J.MOLCATB.2012.02.006 7;
XINRUI ZHOU ET AL: "Recombinant purine nucleoside phosphorylases from thermophiles: preparation, properties and activity towards purine and pyrimidine nucleosides", FEBS JOURNAL, vol. 280, no. 6, 21 March 2013 (2013-03-21), pages 1475 - 1490, XP055175902, ISSN: 1742-464X, DOI: 10.1111/febs.12143 7;
XINRUI ZHOU: "Thermostable Nucleoside Phosphorylases as Biocatalysts for the Synthesis of Purine Nucleoside Analogues Characterisation, immobilization and synthesis", DOCTORAL THESIS, 30 April 2014 (2014-04-30), XP055175917, Retrieved from the Internet [retrieved on 20150312] 7
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| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt |
CTNP |
T. ROBAK ET AL., CURR. PHARM. DES., vol. 18, 2012, pages 3373 - 3388 1;
VLADIMIR N. BARAI ET AL., HELVETICA CHIMICA ACTA, vol. 85, 2002, pages 1901 - 1908 1
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