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Document WO002013050760A2 (Pages: 68)

Bibliographic data Document WO002013050760A2 (Pages: 68)
INID Criterion Field Contents
54 Title TI [EN] COFACTOR REGENERATION SYSTEM
[FR] SYSTÈME DE RÉGÉNÉRATION DE COFACTEURS
71/73 Applicant/owner PA ISIS INNOVATION, GB ; UNIV BERLIN HUMBOLDT, DE
72 Inventor IN LAUTERBACH LARS, DE ; LENZ OLIVER, DE ; VINCENT KYLIE, GB
22/96 Application date AD Oct 3, 2012
21 Application number AN 2012052451
Country of application AC GB
Publication date PUB Apr 11, 2013
33
31
32
Priority data PRC
PRN
PRD
GB
201116971
20111003
51 IPC main class ICM C12P 1/00 (2006.01)
51 IPC secondary class ICS C12N 9/00 (2006.01)
C12P 33/02 (2006.01)
IPC additional class ICA
IPC index class ICI
Cooperative patent classification CPC C12N 9/0036
C12N 9/0051
C12P 19/36
C12Y 106/99001
C12Y 108/01
C12Y 108/01004
MCD main class MCM C12P 1/00 (2006.01)
MCD secondary class MCS C12N 9/00 (2006.01)
C12P 33/02 (2006.01)
MCD additional class MCA
57 Abstract AB [EN] The present invention relates to cofactor regeneration systems, components and uses thereof and methods for generating and regenerating cofactors. The cofactor regeneration system comprises a first electron transfer component selected from a polypeptide comprising a NADH:acceptor oxido-reductase or NADPH:acceptor oxido- reductase, a second electron transfer component selected from a hydrogenase moietyand/or non-biological nanoparticles and an electronically conducting surface. The first and second electron transfer components are immobilised on the electrically conducting surface, and the first and second electron transfer components do not occur together in nature as an enzyme complex.
[FR] La présente invention porte sur des systèmes de régénération de cofacteurs, des composants de ceux-ci et des utilisations de ceux-ci et des procédés pour la production et la régénération de cofacteurs. Le système de régénération de cofacteurs comprend un premier composant de transfert d'électrons choisi parmi des polypeptides comprenant une NADH:accepteur oxydoréductase ou une NADPH:accepteur oxydoréductase, un second composant de transfert d'électrons choisi parmi une fraction hydrogénase et/ou des nanoparticules non biologiques et une surface conductrice du point de vue électronique. Les premier et second composants de transfert d'électrons sont immobilisés sur la surface électroconductrice et les premier et second composants de transfert d'électrons n'apparaissent pas ensemble dans la nature sous forme d'un complexe enzymatique.
56 Cited documents identified in the search CT
56 Cited documents indicated by the applicant CT
56 Cited non-patent literature identified in the search CTNP
56 Cited non-patent literature indicated by the applicant CTNP ALTSCHUL ET AL., BULL. MATH. BIO., vol. 48, 1986, pages 603 - 16 1;
C. E. LAWRENCE ET AL.: "Detecting Subtle Sequence Signals: A Gibbs Sampling Strategy for Multiple Alignment", SCIENCE, vol. 262, no. 5131, 1993, pages 208 - 214, XP001152872, DOI: doi:10.1126/science.8211139 1;
JULIE D. THOMPSON ET AL.: "CLUSTAL W: Improving the Sensitivity of Progressive Multiple Sequence Alignment Through Sequence Weighting, Position- Specific Gap Penalties and Weight Matrix Choice", NUCLEIC ACIDS RESEARCH, vol. 22, no. 22, 1994, pages 4673 - 4680, XP002956304 1;
LAUTERBACH ET AL., PLOS ONE 1;
OSAMU GOTOH: "Significant Improvement in Accuracy of Multiple Protein. Sequence Alignments by Iterative Refinement as Assessed by Reference to Structural Alignments", J. MOL. BIOL., vol. 264, no. 4, 1996, pages 823 - 838 1;
ERIC DEPIEREUX; ERNEST FEYTMANS: "Match-Box: A Fundamentally New Algorithm for the Simultaneous Alignment of Several Protein Sequences", CABIOS, vol. 8, no. 5, 1992, pages 501 - 509 1;
HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 10915 - 19 1;
IVO VAN WALLE ET AL.: "Align-M - A New Algorithm for Multiple Alignment of Highly Divergent Sequences", BIOINFORMATICS, vol. 20, no. 9, 2004, pages 1428 - 1435 1;
REEVE, H.A.; LAUTERBACH, L.; ASH, P.A.; LENZ, O.; VINCENT, K.A.: "A modular system for regeneration of NAD cofactors using graphite particles modified with hydrogenase and diaphorase moieties", CHEM. COMMUN., vol. 48, no. 10, 2012, pages 1589 - 1591 1;
VINCENT, K. A.; PARKIN, A.; LENZ, O.; ALBRACHT, S. P. J.; FONTECILLA-CAMPS, J. C.; CAMMACK, R.; FRIEDRICH, B.; ARMSTRONG, F. A.: "Electrochemical Definitions of 02 Sensitivity and Oxidative Inactivation in Hydrogenases", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 127, 2005, pages 18179 - 18189 1
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C12P 33/02