Bibliografische Daten

Dokument WO002011157655A1 (Seiten: 57)

Bibliografische Daten Dokument WO002011157655A1 (Seiten: 57)
INID Kriterium Feld Inhalt
54 Titel TI [EN] USE OF BILE ACIDS FOR PREDICTION OF AN ONSET OF SEPSIS
[FR] UTILISATION DES ACIDES DE LA BILE POUR LA PRÉDICTION D'UNE APPARITION DE SEPSIE
71/73 Anmelder/Inhaber PA BAUER MICHAEL, DE ; BIOCRATES LIFE SCIENCES AG, AT ; DALLMANN GUIDO, AT ; DEIGNER HANS-PETER, DE ; ENOT DAVID, FR ; IGWE IGNATIUS EMEKA, AT ; KOAL THERESE, AT ; KOHL MATTHIAS, DE
72 Erfinder IN BAUER MICHAEL, DE ; DALLMANN GUIDO, AT ; DEIGNER HANS-PETER, DE ; ENOT DAVID, FR ; IGWE IGNATIUS EMEKA, AT ; KOAL THERESE, AT ; KOHL MATTHIAS, DE
22/96 Anmeldedatum AD 10.06.2011
21 Anmeldenummer AN 2011059699
Anmeldeland AC EP
Veröffentlichungsdatum PUB 22.12.2011
33
31
32
Priorität PRC
PRN
PRD
EP
10165974
20100615
51 IPC-Hauptklasse ICM G01N 33/50 (2006.01)
51 IPC-Nebenklasse ICS G01N 33/92 (2006.01)
IPC-Zusatzklasse ICA
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC G01N 2030/8813
G01N 2800/24
G01N 2800/26
G01N 2800/50
G01N 30/7233
G01N 33/6848
G01N 33/6893
G01N 33/92
MCD-Hauptklasse MCM G01N 33/50 (2006.01)
MCD-Nebenklasse MCS G01N 33/92 (2006.01)
MCD-Zusatzklasse MCA
57 Zusammenfassung AB [EN] The present invention relates to a method for in vitro predicting the likelihood of an onset of sepsis, by quantitatively detecting in at least one biological sample of a patient a plurality of endogenous sepsis predictive target compounds having a molecular weight of less than 1500 Dalton comprising the steps of: selecting said compounds from the group of bile acids, measuring concentration, level or amount of each individual endogenous sepsis predictive target compound of said plurality of compounds in said sample, establishing a quantitative pattern; and using and storing the obtained set of values in a database. Calibrating said values by comparing clinically confirmed sepsis-positive and/or clinically confirmed sepsis-negative reference parameters, and comparing said measured values in the sample with the calibrated values, in order to assess whether the patient is likely to develop a sepsis or not.
[FR] La présente invention concerne un procédé servant à prédire in vitro l'apparition d'une sepsie, en détectant quantitativement dans au moins un échantillon biologique d'un patient une pluralité de composés cibles prédictifs d'une sepsie endogène dont le poids moléculaire est inférieur à 1500 daltons, dont les étapes consistent : à sélectionner lesdits composés parmi le groupe des acides de la bile, à mesurer la concentration, le niveau ou la quantité de chaque composé cible prédictif d'une sepsie endogène de ladite pluralité de composés dans ledit échantillon, à établir un motif quantitatif ; à utiliser et à mémoriser l'ensemble de valeurs obtenu dans une bases de données ; et à étalonner lesdites valeurs en comparant des paramètres de référence positifs d'une sepsie confirmés cliniquement et/ou négatifs d'une sepsie confirmés cliniquement, et à comparer lesdites valeurs mesurées dans l'échantillon aux valeurs calibrées afin d'évaluer si le patient risque de développer une sepsie ou non.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT
56 Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt
CT EP000009167018A
US020080050829A1
WO002006071583A2
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt
CTNP CASTAÑO GUSTAVO ET AL: "Bile acid profiles by capillary electrophoresis in intrahepatic cholestasis of pregnancy.", CLINICAL SCIENCE (LONDON, ENGLAND : 1979) APR 2006 LNKD- PUBMED:16356162, vol. 110, no. 4, April 2006 (2006-04-01), pages 459 - 465, XP002655695, ISSN: 0143-5221 7;
CLAUS R A ET AL: "Approaching clinical reality: markers for monitoring systemic inflammation and sepsis", CURRENT MOLECULAR MEDICINE, BENTHAM SCIENCE PUBLISHERS, NL, vol. 10, no. 2, 1 March 2010 (2010-03-01), pages 227 - 235, XP009136621, ISSN: 1566-5240 7;
INSTITUTE FOR STATISTICS AND MATHEMATICS OF THE WU WIEN: "The R Project for Statistical Computing", 2009, XP002599831, Retrieved from the Internet [retrieved on 20100908] 7;
JANZEN N ET AL: "Rapid quantification of conjugated and unconjugated bile acids and C-27 precursors in dried blood spots and small volumes of serum", JOURNAL OF LIPID RESEARCH, vol. 51, no. 6, January 2010 (2010-01-01), pages 1591 - 1598, XP002655694, ISSN: 0022-2275 7;
KOSTERS ASTRID ET AL: "The Role of Inflammation in Cholestasis: Clinical and Basic Aspects", SEMINARS IN LIVER DISEASE, vol. 30, no. 2, May 2010 (2010-05-01), pages 186 - 194, XP009150894, ISSN: 0272-8087 7;
MURACA M ET AL: "Serum bile acids and esterified bilirubin in early detection and differential diagnosis of hepatic dysfunction following orthotopic liver transplantation.", JOURNAL OF HEPATOLOGY FEB 1993 LNKD- PUBMED:8445227, vol. 17, no. 2, February 1993 (1993-02-01), pages 141 - 145, XP002599830, ISSN: 0168-8278 7;
SUN B ET AL: "Sepsis and septic shock study in pediatric critical care: An overview of recent Chinese literature", JOURNAL OF PEDIATRIC INFECTIOUS DISEASES,, vol. 4, no. 2, 16 March 2009 (2009-03-16), pages 147 - 152, XP009136723, ISSN: 1305-7707 7
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt
CTNP "Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis", CRIT CARE MED, vol. 20, no. 6, 1992, pages 864 - 874, XP008036965 1;
"R: A Language and Environment for Statistical Computing", R DEVELOPMENT CORE TEAM, R FOUNDATION FOR STATISTICAL COMPUTING, 2010, pages 3 - 900051,07-0, XP002599832 1;
"R: A Language and Environment for Statistical Computing", R DEVELOPMENT CORE TEAM, R FOUNDATION FOR STATISTICAL COMPUTING,VIENNA, AUSTRIA, 2010, XP002599832 1;
ANNANE D, AEGERTER P, JARS-GUINCESTRE MC, GUIDET B.: "Current epidemiology of septic shock: the CUB-Rea Network", AM. J. RESPIR. CRIT. CARE MED., vol. 168, 2003, pages 165 - 72 1;
BEGER HG, RAU BM: "Severe acute pancreatitis: Clinical course and management World", J. GASTROENTEROL., vol. 13, 2007, pages 5043 - 51 1;
BENJAMINI Y., HOCHBERG Y.: "Controlling the false discovery rate: a practical and powerful approach to multiple testing", JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B, vol. 57, 1995, pages 289 - 300 1;
BERNARD GR, VINCENT JL, LATERRE PF ET AL.: "Efficacy and safety of recombinant human activated protein C for severe sepsis", N. ENGL. J. MED., vol. 344, 2001, pages 699 - 709 1;
CRIT CARE MED., vol. 20, no. 6, pages 864 - 874 1;
FERREIRA FL, BOTA DP, BROSS A ET AL.: "Serial evaluation of the SOFA score to predict outcome in critically ill patients", JAMA, vol. 286, 2002, pages 1754 - 1758 1;
FERREIRA FL, BOTA DP, BROSS A, MELOT C, VINCENT JL: "Serial evaluation of the SOFA score to predict outcome in critically ill patients", JAMA, vol. 286, no. 14, 2001, pages 1754 - 1758 1;
HASTIE T., TIBSHIRANI R, NARASIMHAN B., CHU G., IMPUTATION FOR MICROARRAY DATA 1;
HASTIE T., TIBSHIRANI R., NARASIMHAN B., CHU G., IMPUTATION FOR MICROARRAY DATA 1;
HIGASHI T, ICHIKAWA T, INAGAKI S, MIN JZ, FUKUSHIMA T, TOYO'OKA T, J PHARM BIOMED ANAL., vol. 52, no. 5, 5 September 2010 (2010-09-05), pages 809 - 18 1;
LEVY M, FINK M, MITCHELL P, MARSHALL JC, ABRAHAM E ET AL., INTERNATIONAL SEPSIS DEFINITIONS CONFERENCE. 2001 SCCM/ESICM/ACCP/ATS/SIS, 2001 1;
MARSHALL JC, COOK DJ, CHRISTOU NV ET AL.: "Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome", CRIT CARE MED, vol. 23, 1995, pages 1638 - 1652, XP008062039, DOI: doi:10.1097/00003246-199510000-00007 1;
MOYER, E. ET AL.: "Multiple Systems Organ Failure: VI. Death Predictors in the Trauma-Septic State - The Most Critical Determinants", THE JOURNAL OF TRAUMA, vol. 21, 1981, pages 862 - 869, XP009129143 1;
SEBOK A, SEZER K, VASANITS-ZSIGRAI A, HELENKAR A, ZARAY G, MOLNÁR-PERL . J, CHROMATOGR A., vol. 1211, no. 1-2, 30 September 2008 (2008-09-30), pages 104 - 12 1;
SMYTH G.K: "Bioinformatics and Computational Biology Solutions using R and Bioconductor", SPRINGER, article "Limma: linear models for microarray data", pages: 397 - 420 1;
SMYTH G.K: "Bioinformatics and Computational Biology Solutions using R and Bioconductor", SPRINGER, pages: 397 - 420 1;
WISHART DS ET AL.: "HMDB: the Human Metabolome Database", NUCLEIC ACIDS RES., vol. 35, January 2007 (2007-01-01), pages D521 - 6 1;
XU, PING-BO ET AL.: "A metabolomic approach to early prognostic evaluation of experimental sepsis", JOURNAL OF INFECTION, vol. 56, 2008, pages 474 - 481, XP022690620, DOI: doi:10.1016/j.jinf.2008.03.011 1
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