Bibliografische Daten

Dokument WO002011000753A1 (Seiten: 167)

Bibliografische Daten Dokument WO002011000753A1 (Seiten: 167)
INID Kriterium Feld Inhalt
54 Titel TI [EN] METHOD FOR NORMALIZATION IN METABOLOMICS ANALYSIS METHODS WITH ENDOGENOUS REFERENCE METABOLITES
[FR] PROCÉDÉ DE NORMALISATION DANS DES PROCÉDÉS D'ANALYSE MÉTABOLIQUE AU MOYEN DE MÉTABOLITES DE RÉFÉRENCE ENDOGÈNES
71/73 Anmelder/Inhaber PA BIOCRATES LIFE SCIENCES AG, AT ; DEIGNER HANS-PETER, DE ; KELLER MATTHIAS, DE ; KOAL THERESE, AT ; KOHL MATTHIAS, DE
72 Erfinder IN DEIGNER HANS-PETER, DE ; KELLER MATTHIAS, DE ; KOAL THERESE, AT ; KOHL MATTHIAS, DE
22/96 Anmeldedatum AD 23.06.2010
21 Anmeldenummer AN 2010058911
Anmeldeland AC EP
Veröffentlichungsdatum PUB 06.01.2011
33
31
32
Priorität PRC
PRN
PRD
EP
09164410
20090702
51 IPC-Hauptklasse ICM G06F 19/00 (2011.01)
51 IPC-Nebenklasse ICS
IPC-Zusatzklasse ICA
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC G01N 2800/60
G16B 40/00
G16B 40/10
G16B 40/20
Y02A 90/10
Y10T 436/163333
Y10T 436/201666
MCD-Hauptklasse MCM G06F 19/00 (2011.01)
G16B 40/10 (2019.01)
MCD-Nebenklasse MCS G16B 40/20 (2019.01)
MCD-Zusatzklasse MCA
57 Zusammenfassung AB [EN] The present invention relates to the use of endogenous reference metabolites and a method for normalization of intensity data corresponding to amounts and/or concentrations of selected target metabolites in a biological sample of a mammalian subject, wherein said intensity data are obtained by a metabolomics analysis method with one or a plurality of endogenous reference metabolites, comprising carrying out at least one in vitro metabolomics analysis method of said selected target metabolites in said biological sample, simultaneously carrying out in the same sample a quantitative analysis of one or a plurality of endogenous reference metabolites or derivatives thereof, wherein said endogenous reference metabolites are such compounds in the biological sample which are present in the subject at an essentially constant level; and wherein said endogenous reference metabolites or derivatives thereof have a molecular mass less than 1500 Da.
[FR] La présente invention porte sur l'utilisation de métabolites de référence endogènes et sur un procédé de normalisation de données d'intensité correspondant à des quantités et/ou des concentrations de métabolites cibles sélectionnés dans un échantillon biologique d'un mammifère, lesdites données d'intensité étant obtenues par un procédé d'analyse métabolique avec un ou une pluralité de métabolites de référence endogènes, comprenant la réalisation d'au moins un procédé d'analyse métabolique in vitro desdits métabolites cibles sélectionnés dans ledit échantillon biologique, la réalisation simultanée dans le même échantillon d'une analyse quantitative d'un ou plusieurs des métabolites de référence endogènes ou dérivés de ceux-ci, lesdits métabolites de référence endogènes étant des composés de l'échantillon biologique présents chez le sujet à un niveau fondamentalement constant, et lesdits métabolites de référence endogènes ou dérivés de ceux-ci ayant une masse moléculaire inférieure à 1.500 Da.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT
56 Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt
CT US000007277807B2
WO002007008307A2
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt
CTNP ANDERSEN CLAUS LINDBJERG ET AL: "Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.", CANCER RESEARCH 1 AUG 2004, vol. 64, no. 15, 1 August 2004 (2004-08-01), pages 5245 - 5250, XP008112436, ISSN: 0008-5472 7;
DIXON S J ET AL: "Pattern recognition of gas chromatography mass spectrometry of human volatiles in sweat to distinguish the sex of subjects and determine potential discriminatory marker peaks", CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 20070615 NL, vol. 87, no. 2, 15 June 2007 (2007-06-15), pages 161 - 172, XP022081779, ISSN: 0169-7439 7;
ENOT DAVID P ET AL: "Preprocessing, classification modeling and feature selection using flow injection electrospray mass spectrometry metabolite fingerprint data.", NATURE PROTOCOLS 2008, vol. 3, no. 3, 2008, pages 446 - 470, XP001539671, ISSN: 1750-2799 7;
SYSI-AHO MARKO ET AL: "Normalization method for metabolomics data using optimal selection of multiple internal standards", BMC BIOINFORMATICS, vol. 8, March 2007 (2007-03-01), XP021021881, ISSN: 1471-2105 7;
VANDESOMPELE JO ET AL: "Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes.", GENOME BIOLOGY 18 JUN 2002, vol. 3, no. 7, 18 June 2002 (2002-06-18), XP008027995, ISSN: 1465-6914 7;
WARRACK B M ET AL: "Normalization strategies for metabonomic analysis of urine samples", JOURNAL OF CHROMATOGRAPHY B: ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 20090215 ELSEVIER NL, vol. 877, no. 5-6, 15 February 2009 (2009-02-15), pages 547 - 552, XP025928077 7
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt
CTNP ANDERSEN ET AL.: "Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets", CANCER RESEARCH, vol. 64, 2004, pages 5245 - 5250 1;
B. M. WARRACK; S. HNATYSHYN; K.-H. OTT; M.D. REILY; M. SANDERS; H. ZHANG; D.M. DREXLER, JOURNAL OF CHROMATOGRAPHY, vol. 877, no. 5-6, 2009, pages 547 - 552 1;
B. M. WARRACK; S. HNATYSHYN; K.-H. OTT; M.D. REILY; M. SANDERS; H. ZHANG; D.M. DREXLER: "Normalization strategies for metabolomic analysis of urine samples", JOURNAL OF CHROMATOGRAPHY B, vol. 877, no. 5-6, 2009, pages 547 - 552 1;
BENJAMINI Y.; HOCHBERG Y.: "Controlling the false discovery rate: a practical and powerful approach to multiple testing", JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B, vol. 57, 1995, pages 289 - 300 1;
BOX G.E.P.; COX D.R.: "An analysis of transformations (with discussion)", JOURNAL OF THE ROYAL STATISTICAL SOCIETY B, vol. 26, 1964, pages 211 - 252 1;
BOX, G. E. P.; COX, D. R.: "An analysis of transformations (with discussion)", JOURNAL OF THE ROYAL STATISTICAL SOCIETY B, vol. 26, 1964, pages 211 - 252 1;
D.P. ENOT; W. LIN; M. BECKMANN; D. PARKER; D.P. OVERY; J. DRAPER, NATURE PROTOCOLS, vol. 3, 2008, pages 446 - 470 1;
F. DIETERLE; A. ROSS, G; SCHLOTTERBECK; H. SENN, ANAL CHEM, vol. 78, no. 13, 2006, pages 4281 - 90 1;
F. DIETERLE; A. ROSS; G. SCHLOTTERBECK; H. SENN: "Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1 H NMR metabolomics", ANAL CHEM., vol. 78, no. 13, 2006, pages 4281 - 90 1;
HOLM, S.: "A simple sequentially rejective multiple test procedure. Scandinavian", JOURNAL OF STATISTICS, vol. 6, 1979, pages 65 - 70 1;
HUBER W.; VON HEYDEBRECK A.; SUELTMANN H.; POUSTKA A.; VINGRON M.: "Variance stabilization applied to microarray data calibration and to the quantification of differential expression", BIOINFORMATICS, vol. 18, no. 1, 2002, pages S96 - S104 1;
L.M. COPE ET AL.: "A Benchmark for Affymetrix GeneChip Expression Measures", BIOINFORMATICS, vol. 20, no. 3, 2004, pages 323 - 331 1;
LIN S.M.; DU P.; HUBER W.; KIBBE, W.A.: "Model-based variance-stabilizing transformation for Illumina microarray data", NUCLEIC ACIDS RESEARCH, vol. 36, no. 2, 2008, pages E11 1;
M. SYSI-AHO; M. KATAJAMAA, L; YETUKURIL; M. ORESIC, BMC BIOINFORMATICS, vol. 8, no. 93, 2007 1;
M. SYSI-AHO; M. KATAJAMAA; L. YETUKURIL; M. ORESIC: "Normalization method for metabolomics data using optimal selection of multiple internal standards", BMC BIOINFORMATICS, vol. 8, 2007, pages 93 1;
P. WANG; H. TANG; H. ZHANG; J. WHITEAKER; A. G. PAULOVICH; M. MCINTOSH, PACIFIC SYMPOSIUM ON BIOCOMPUTING, vol. 11, 2006, pages 315 - 326 1;
P. WANG; H. TANG; H. ZHANG; J. WHITEAKER; A. G. PAULOVICH; M. MCINTOSH: "Normalization Regarding Non-Random Missing Values in High-Throughput Mass Spectrometry Data", PACIFIC SYMPOSIUM ON BIOCOMPUTING, vol. 11, 2006, pages 315 - 326 1;
R. GOODACRE; S. VAIDYANATHAN; W.B. DUNN; G. HARRIGAN; D.B. KELL, TRENDS IN BIOTECHNOLOGY, vol. 22, no. 5, 2004, pages 245 - 252 1;
R. GOODACRE; S. VAIDYANATHAN; W.B. DUNN; G. HARRIGAN; D.B. KELL: "Metabolomics by numbers: acquiring and understanding global metabolite data", TRENDS IN BIOTECHNOLOGY, vol. 22, no. 5, 2004, pages 245 - 252 1;
R.A. IRIZARRY ET AL.: "Comparison of Affymetrix GeneChip Expression Measures", BIOINFORMATICS, vol. 22, no. 7, 2006, pages 789 - 794 1;
R.J.O. TORGRIP; K.M. ABERGL; E. AIM; SCHUPPE-KOISTINEN; J. LINDBERG, METABOLOMICS, vol. 4, no. 2, 2008, pages 114 - 121 1;
R.J.O. TORGRIP; K.M. ABERGL; E. AIM; SCHUPPE-KOISTINEN; J. LINDBERG: "A note on normalization of biofluid 1D 1 H-NMR data", METABOLOMICS, vol. 4, no. 2, 2008, pages 114 - 121 1;
S. BIJLSMA; L. BOBELDIJK; E.R. VERHEIJ; R. RAMAKER; S. KOCHHAR; A. MACDONALD; B. VAN OMMEN; A.K. SMILDE, ANAL. CHEM, vol. 78, no. 2, 2006, pages 567 - 574 1;
UNTERWURZACHER, CLIN CHEM LAB MED, vol. 46, no. 11, 2008, pages 1589 - 1597 1;
VANDESOMPELE ET AL.: "Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes", GENOME BIOLOGY, vol. 3, no. 7, 2002 1;
VANDESOMPELE ET AL.: "Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes", GENOME BIOLOGY, vol. 3, no. 7, 2002, pages 0034.1 - 0034.11 1;
WISHART DS ET AL.: "HMDB: the Human Metabolome Database", NUCLEIC ACIDS RES., vol. 35, January 2007 (2007-01-01), Retrieved from the Internet 1
Zitierende Dokumente Dokumente ermitteln
Sequenzprotokoll
Prüfstoff-IPC ICP