| 54 |
Titel |
TI |
[EN] SLIPPERY MICROPROPELLERS PENETRATE THE VITREOUS HUMOR |
| 71/73 |
Anmelder/Inhaber |
PA |
MAX PLANCK INNOVATION GMBH, DE
|
| 72 |
Erfinder |
IN |
FISCHER PEER, DE
;
QIU TIAN, DE
;
WU ZHIGUANG, DE
|
| 22/96 |
Anmeldedatum |
AD |
21.08.2018 |
| 21 |
Anmeldenummer |
AN |
201816641059 |
|
Anmeldeland |
AC |
US |
|
Veröffentlichungsdatum |
PUB |
10.06.2021 |
33
31
32 |
Priorität |
PRC
PRN
PRD |
EP
2018072501
21.08.2018
|
33
31
32 |
PRC
PRN
PRD |
EP
17187924
25.08.2017
|
| 51 |
IPC-Hauptklasse |
ICM |
A61K 49/18
(2006.01)
|
| 51 |
IPC-Nebenklasse |
ICS |
A61K 41/00
(2020.01)
A61K 45/06
(2006.01)
A61K 9/00
(2006.01)
|
|
IPC-Zusatzklasse |
ICA |
|
|
IPC-Indexklasse |
ICI |
|
|
Gemeinsame Patentklassifikation |
CPC |
A61F 9/0017
A61K 41/00
A61K 45/06
A61K 49/1824
A61K 9/0009
A61K 9/0051
A61K 9/0085
B82Y 25/00
B82Y 5/00
|
|
MCD-Hauptklasse |
MCM |
A61K 49/18
(2006.01)
|
|
MCD-Nebenklasse |
MCS |
A61K 41/00
(2020.01)
A61K 45/06
(2006.01)
A61K 9/00
(2006.01)
|
|
MCD-Zusatzklasse |
MCA |
|
| 57 |
Zusammenfassung |
AB |
[EN] Microparticles actively propel through the vitreous humour and reach the retina in porcine eyes. The slippery micro helical propellers are constructed by the combination of glancing angle deposition technique and the fusion of the slippery liquid layer. The magnetically propulsion in the vitreous humour relies on the matched size of the propeller to the collagen network of the vitreous, and the anti-adhesion coating of the collagen fiber bundles. Clinical optical coherence tomography observed the displacement of the slippery micropropellers through the vitreous to the macular area on the retina. The slippery micropropellers realize the controllable massive movements to the retina in 30 mins, while exerting the travelling distance of above one centimeter. The injection of the slippery micropropellers, the magnetically-powered controllable propulsion in the vitreous, and the optical coherence tomography imaging technique, constitute an intact method for rapid targeted ocular delivery, providing a promising approach towards ophthalmologic applications. |
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt |
CT |
US020190247525A1
|
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt |
CT |
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt |
CTNP |
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt |
CTNP |
|
|
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Prüfstoff-IPC |
ICP |
A61F 9/00
A61K 41/00
A61K 49/18
A61K 9/00
B82Y 25/00
B82Y 5/00
|
