| 72 |
Erfinder |
IN |
EBER FABIAN JOHANNES, DE
;
KETTERER THOMAS, DE
;
KOLLAND KATHARINA, DE
;
MUTZKE THORSTEN, DE
;
ROOS TILMANN, DE
;
SEWING STEFANIE, DE
;
SONNTAG MICHAEL, DE
;
WIGGENHORN MICHAEL, DE
;
YAZDAN PANAH BENYAMIN, DE
|
| 57 |
Zusammenfassung |
AB |
[EN] The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule. |
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt |
CTNP |
“Mini-Buchi Spray Dryer,” technical specification sheet downloaded from Buchi.com on May 20, 2019. 1;
International Preliminary Report Patentability issued in corresponding PCT Application No. PCT/EP2016/000843, dated Nov. 15, 2016. 1;
International Search Report and Written Opinion issued in corresponding PCT Application No. PCT/EP2016/000843, dated Nov. 15, 2016. 1;
Jensen et al., “Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation,” J. Control. Release, 142(1):138-145, 2010. 1;
Office Action issued in U.S. Appl. No. 15/575,284, dated Aug. 28, 2018. 1;
Office Action issued in U.S. Appl. No. 15/575,284, dated May 23, 2019. 1;
Office Action issued in U.S. Appl. No. 15/575,284, dated Nov. 16, 2018. 1;
Qiu et al., “Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide,” Journal of Controlled Release, 314:102-115, 2019. 1
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