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Abstract |
AB |
[EN] There is disclosed the use of mesembrine and related compounds (e.g. mesembranol, mesembranone) as scrotonin-uptake inhibitors, pharmaceutical compositions comprising such compounds or dry material or an extract of plants from the Mesembryanthemaceae family (e.g. Sceletium (Aizoaceae) tortuosum) containing a standardized content of said compounds, for use in the treatment of depressive states, psychological or psychiatric disorders with an anxiety component, alcohol and drug dependence, bulimia nervosa and obsessive-compulsive disorders. Also disclosed are new derivatives of mesembrine. |
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Cited non-patent literature indicated by the applicant |
CTNP |
Capps et al., "Sceletium Alkaloids, Part 7.1 Structure and Absolute Stereochemistry of (-)-Mesembrane and 3'-Methoxy-4'-O-methyljoubertiamine, Two Minor Bases from S. Namaquense L. Bolus: X-Ray Analysis of (-)-Mesembrane Hydrochloride Monohydrate," J. Chem. Soc. Perkins Trans. 8:1098-1104 (1977). 1;
Hoshino et al., "Synthesis of Sceletium and Amaryllidaceae Alkaloids, (±)-Mesembrine and (±)-Dihydromaritidine, (±)Epidihydromaritidine, (±-Elwesine, and (±)-Epielwesine1)," Chem. Pharm. Bull. 35:2734-2743 (1987). 1;
Jeffs et al., "Sceletium Alkaloids. VI. Minor Alkaloids of S. namaquense and S. strictum," J. Org. Chem. 39:2703-2710 (1974). 1;
Jeffs et al., "Total Syntheses of (±)-Joubertinamine, and (±)-N-Demethylmesembrenone," J. Org. Chem. 48:3861-3863 (1983). 1;
Kruger et al., "Minor Alkaloids from Sceletium Strictum L. Bol. The Structure of N-Demethylmesembrenol and N-Demthylmesembranol," Journal of the South African Chemical Institute XXIV:235-237 (1971). 1;
Langlois et al., "Recherches Dans La Serie Des Aryl-3 Pyrrolidines-II, Syntheses de Produits Apparentes a la Mesembrine et a La Crinine," Tetrahedron 27:5641-5652 (1971). 1;
Pfaffli et al., "Demethylierungen am Mesembrine," Helvetica Chimica Acta 56:347-355 (1973). 1;
Smith et al., "Psychoactive constituents of the genus Sceletium N.E.Br. and otehr Mesembryanthemaceae: a review," Journal of Ethnopharmacology 50:119-130 (1996). 1;
Taguchi et al., "Synthesis of Octahydroindole Derivatives," Tetrahedrom Letters, 55:5763-5766 (1968). 1;
Taguchi et al., "Synthesis of Octhydroindole Derivatives," Chem. Pharm. Bull. 18:1008-1014 (1970). 1
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