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Dokument US000005514548A (Seiten: 20)

Bibliografische Daten Dokument US000005514548A (Seiten: 20)
INID Kriterium Feld Inhalt
54 Titel TI [EN] Method for in vivo selection of ligand-binding proteins
71/73 Anmelder/Inhaber PA MORPHOSYS GES FUR PROTEINOPTIM, DE
72 Erfinder IN KREBBER CLAUS, CH ; MORONEY SIMON, DE ; PLUECKTHUN ANDREAS, CH ; SCHNEIDER CHRISTIAN, DE
22/96 Anmeldedatum AD 17.02.1994
21 Anmeldenummer AN 19777094
Anmeldeland AC US
Veröffentlichungsdatum PUB 07.05.1996
33
31
32
Priorität PRC
PRN
PRD
EP
93102484
19930217
51 IPC-Hauptklasse ICM C12Q 1/68
51 IPC-Nebenklasse ICS C12N 15/64
C12N 15/70
IPC-Zusatzklasse ICA
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC C12N 15/1037
C12Q 1/686
C12Q 1/70
C40B 40/02
MCD-Hauptklasse MCM C12N 1/21 (2006.01)
MCD-Nebenklasse MCS C12N 15/09 (2006.01)
C12N 15/10 (2006.01)
C12N 7/00 (2006.01)
C12Q 1/686 (2018.01)
C12Q 1/68 (2006.01)
C12Q 1/70 (2006.01)
C40B 40/02 (2006.01)
G01N 33/53 (2006.01)
G01N 33/566 (2006.01)
MCD-Zusatzklasse MCA
57 Zusammenfassung AB [EN] The application discloses a method, and kit, which enables the selection of proteins or other oligo- or polypeptides (collectively, ligand binding proteins, LBPs) which bind with high affinity to a target ligand or receptor. The method relies on the display of the LBP of interest on the surface of replicable genetic packages (RGPs) which are modified so as to be non-infective. Infectivity is restored to those RGPs displaying LBPs with high affinity for a target ligand or receptor by an infectivity mediating complex. The infectivity mediating complex comprises the ligand or receptor covalently linked to a polypeptide which brings about interaction between the RGP and a host cell. It is envisaged that the LBP of interest will belong to a genetically diverse collection of similar substances. The method therefore allows selection of substances with high affinity for target, from within a large collection of variants.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT WO001992001047A1
56 Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt
CT
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56 Entgegengehaltene Nichtpatentliteratur/Zitate,
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CTNP
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Prüfstoff-IPC ICP C12N 15/64
C12N 15/70
C12Q 1/68