| 54 |
Title |
TI |
[DE] SELBSTANORDNENDE PEPTIDAMPHIPHILE ALS VERSTÄRKER DER RETROVIRALEN TRANSDUKTION
[EN] SELF-ASSEMBLING PEPTIDE AMPHIPHILES AS RETROVIRAL TRANSDUCTION ENHANCERS
[FR] AMPHIPHILES PEPTIDIQUES À AUTO-ASSEMBLAGE EN TANT QU'ACTIVATEURS DE TRANSDUCTION RÉTROVIRALE |
| 71/73 |
Applicant/owner |
PA |
MAX PLANCK GESELLSCHAFT, DE
|
| 72 |
Inventor |
IN |
|
| 22/96 |
Application date |
AD |
May 3, 2023 |
| 21 |
Application number |
AN |
23171438 |
|
Country of application |
AC |
EP |
|
Publication date |
PUB |
Nov 6, 2024 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
|
| 51 |
IPC main class |
ICM |
C12N 15/87
(2006.01)
|
| 51 |
IPC secondary class |
ICS |
A61K 31/00
(2006.01)
B82Y 5/00
(2011.01)
C07K 7/00
(2006.01)
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
C07K 7/06
C07K 7/08
C12N 15/86
C12N 15/87
C12N 2740/16011
|
|
MCD main class |
MCM |
C12N 15/87
(2006.01)
|
|
MCD secondary class |
MCS |
A61K 31/00
(2006.01)
B82Y 5/00
(2011.01)
C07K 7/00
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[EN] The present invention relates to self-assembling peptide amphiphiles consisting of a non-self-assembling peptide moiety having a positive net charge under physiological pH, and a hydrophobic moiety covalently coupled to the peptide moiety, wherein the peptide moiety is composed of a positively charged peptide part and a &bgr;-sheet forming peptide part, wherein the hydrophobic moiety is covalently coupled to the &bgr;-sheet forming peptide part, wherein the peptide amphiphiles self-assemble into fibrils and form µm-sized aggregates in aqueous medium, and wherein the fibrils are efficiently degradable in cells. The peptide amphiphiles of the present invention are useful as viral transduction enhancers for retroviral gene delivery into cells. Thus, the present invention further relates to the use of peptide amphiphiles as retroviral transduction enhancers in retroviral gene delivery into cells, and to methods for retroviral gene delivery into cells in presence of peptide amphiphiles. |
| 56 |
Cited documents identified in the search |
CT |
WO002003054146A2
|
| 56 |
Cited documents indicated by the applicant |
CT |
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
KOLBERG-EDELBROCK J ET AL: "Biomimetic Extracellular Scaffolds by Microfluidic Superstructuring of Nanofibers", ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 9, no. 3, 21 February 2023 (2023-02-21), pages 1251 - 1260, XP093092438, ISSN: 2373-9878, Retrieved from the Internet DOI: 10.1021/acsbiomaterials.2c01098 0;
SIESTE S ET AL: "Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction", ADVANCED FUNCTIONAL MATERIALS, vol. 31, no. 17, 22 February 2021 (2021-02-22), DE, pages 1 - 12, XP093092532, ISSN: 1616-301X, Retrieved from the Internet DOI: 10.1002/adfm.202009382 0
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
|
|
Citing documents |
|
Determine documents
|
|
Sequence listings |
|
|
|
Search file IPC |
ICP |
A61K 31/00
B82Y 5/00
C12N 15/86
C12N 15/87
|
