| 54 |
Titel |
TI |
[DE] PEPTID MIT ANTIMIKROBIELLER WIRKUNG
[EN] PEPTIDE WITH ANTIMICROBIAL ACTIVITY
[FR] PEPTIDE À ACTIVITÉ ANTIMICROBIENNE |
| 71/73 |
Anmelder/Inhaber |
PA |
UNIV BERLIN FREIE, DE
|
| 72 |
Erfinder |
IN |
CHOWDHARY SUVRAT, DE
;
FULDE MARCUS, DE
;
KOKSCH BEATE, DE
;
PELZER TIM, DE
|
| 22/96 |
Anmeldedatum |
AD |
22.11.2022 |
| 21 |
Anmeldenummer |
AN |
22208808 |
|
Anmeldeland |
AC |
EP |
|
Veröffentlichungsdatum |
PUB |
29.05.2024 |
33
31
32 |
Priorität |
PRC
PRN
PRD |
|
| 51 |
IPC-Hauptklasse |
ICM |
C07K 7/08
(2006.01)
|
| 51 |
IPC-Nebenklasse |
ICS |
A61K 38/10
(2006.01)
A61P 31/04
(2006.01)
|
|
IPC-Zusatzklasse |
ICA |
|
|
IPC-Indexklasse |
ICI |
|
|
Gemeinsame Patentklassifikation |
CPC |
A61K 38/00
A61P 31/04
C07K 7/08
|
|
MCD-Hauptklasse |
MCM |
C07K 7/08
(2006.01)
|
|
MCD-Nebenklasse |
MCS |
A61K 38/10
(2006.01)
A61P 31/04
(2006.01)
|
|
MCD-Zusatzklasse |
MCA |
|
| 57 |
Zusammenfassung |
AB |
[EN] The invention refers to a peptide with antimicrobial activity comprising the following sequence Y1-[R-X1-R-X2-R-dL-dF-[2]Abz-dA-R-X2-R-X1-R]-Y2Wherein R is D-or L- Arginine or an Arginine analogue, dL is D-Leucine, dF is D-Phenylalanine, [2]Abz is 2-Aminobenzoic acid, dA is D-Alanine, X1 is FaHbC - (FcHdC)n -CH2-CHNH2CO2H, wherein a is 0,1, 2, 3; b is 0, 1, 2, 3; wherein the sum of a and b is always 3; c is 0, 1, 2; d is 0, 1, 2; wherein the sum of c and d is always 2; Wherein n is 0-5, X2 is L-Tryptophan (W), D-Tryptophan or a Tryptophan analogue or X1, Y1 is Acetyl or H or any suitable protective group; and Y2 is NH2 or OH or any suitable protective group. |
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt |
CT |
|
| 56 |
Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt |
CT |
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt |
CTNP |
CAMERON ALAN J. ET AL: "-Phe-2-Abz turn motif: Investigations on antimicrobial activity and propensity to adopt [beta]-hairpin conformations", JOURNAL OF PEPTIDE SCIENCE, vol. 24, no. 8-9, E3094, 1 August 2018 (2018-08-01), Hoboken, USA, pages 1 - 10, XP093043393, ISSN: 1075-2617, DOI: 10.1002/psc.3094 0;
CHOWDHARY SUVRAT ET AL: "Rational design of amphiphilic fluorinated peptides: evaluation of self-assembly properties and hydrogel formation", NANOSCALE, vol. 14, no. 28, 21 July 2022 (2022-07-21), United Kingdom, pages 10176 - 10189, XP093043395, ISSN: 2040-3364, DOI: 10.1039/D2NR01648F 0;
MENG HE ET AL: "Antimicrobial Activity and Protease Stability of Peptides Containing Fluorinated Amino Acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 50, 1 December 2007 (2007-12-01), pages 15615 - 15622, XP093043399, ISSN: 0002-7863, DOI: 10.1021/ja075373f 0;
SUSANNE HUHMANN ET AL: "Fine-Tuning the Proteolytic Stability of Peptides with Fluorinated Amino Acids", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2018, 19 July 2018 (2018-07-19), pages 3667 - 3679, XP072121704, ISSN: 1434-193X, DOI: 10.1002/EJOC.201800803 0
|
| 56 |
Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt |
CTNP |
A. A. BERGERJ.-S. VOLLERN. BUDISAB. KOKSCH, ACCOUNTS OF CHEMICAL RESEARCH, vol. 50, 2017, pages 2093 - 2103 1;
D. GIMENEZC. ANDREUM. I. D. OLMOT. VAREAD. DIAZG. ASENSIO, BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, 2006, pages 6971 - 6978 1;
G. WANGX. LIZ. WANG, NUCLEIC ACIDS RES, vol. 44, 2016, pages D1087 - 1093 1;
H. KHANDELIAY. N. KAZNESSIS, THE JOURNAL OF PHYSICAL CHEMISTRY B, vol. 111, 2007, pages 242 - 250 1;
H. MENGK. KUMAR, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, 2007, pages 15615 - 15622 1;
J. N. SLOANDM. A. MILLERS. H. MEDINA, PEPTIDE SCIENCE, vol. 113, 2021, pages e24184 1;
J.-P. S. POWERSR. E. W. HANCOCK, PEPTIDES, vol. 24, 2003, pages 1681 - 1691 1;
L. M. GOTTLERH. Y. LEEC. E. SHELBURNEA. RAMAMOORTHYE. N. MARSH, CHEMBIOCHEM, vol. 9, 2008, pages 370 - 373 1;
L. M. GOTTLERR. DE LA SALUD BEAC. E. SHELBURNEA. RAMAMOORTHYE. N. G. MARSH, BIOCHEMISTRY, vol. 47, 2008, pages 9243 - 9250 1;
M. SALWICZEKE. K. NYAKATURAU. I. M. GERLINGS. YEB. KOKSCH, CHEMICAL SOCIETY REVIEWS, vol. 41, 2012, pages 2135 - 2171 1;
S. C. SETTYS. HORAMM. PASUPULETIW. HAQ, INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, vol. 23, 2017, pages 213 - 225 1;
S. CHOWDHARYR. F. SCHMIDTA. K. SAHOOT. TOM DIECKT. HOHMANNB. SCHADEK. BRADEMANN-JOCKA. F. THUNEMANNR. R. NETZM. GRADZIELSKI, NANOSCALE, vol. 14, 2022, pages 10176 - 10189 1;
T. HOHMANN, M. DYRKS, S. CHOWDHARY, M. WEBER, D. NGUYEN, J. MOSCHNER, B. KOKSCH, THE JOURNAL OF ORGANIC CHEMISTRY, vol. 87, 2022, pages 10592 - 10604 1;
Y. HUANQ. KONGH. MOUH. YI, FRONTIERS IN MICROBIOLOGY, vol. 11, 2020 1
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