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Dokument EP000003925667A1 (Seiten: 114)

Bibliografische Daten Dokument EP000003925667A1 (Seiten: 114)
INID Kriterium Feld Inhalt
54 Titel TI [DE] SELEKTIVE TMPRSS2-INHIBITOREN UND MEDIZINISCHE VERWENDUNG DAVON
[EN] SELECTIVE TMPRSS2 INHIBITORS AND MEDICAL USE THEREOF
[FR] INHIBITEURS SÉLECTIFS DE LA TMPRSS2 ET LEUR UTILISATION MÉDICALE
71/73 Anmelder/Inhaber PA MAX PLANCK GESELLSCHAFT, DE
72 Erfinder IN
22/96 Anmeldedatum AD 17.06.2020
21 Anmeldenummer AN 20180647
Anmeldeland AC EP
Veröffentlichungsdatum PUB 22.12.2021
33
31
32
Priorität PRC
PRN
PRD


51 IPC-Hauptklasse ICM A61P 31/12 (2006.01)
51 IPC-Nebenklasse ICS A61K 38/05 (2006.01)
A61K 38/06 (2006.01)
A61K 38/07 (2006.01)
A61P 31/16 (2006.01)
C07K 5/072 (2006.01)
C07K 5/078 (2006.01)
C07K 5/083 (2006.01)
C07K 5/093 (2006.01)
C07K 5/09 (2006.01)
C07K 5/103 (2006.01)
C07K 5/113 (2006.01)
C07K 5/11 (2006.01)
IPC-Zusatzklasse ICA
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC A61K 38/00
A61K 45/06
A61P 31/12
A61P 31/16
C07K 5/06095
C07K 5/06113
C07K 5/06147
C07K 5/0806
C07K 5/0817
C07K 5/0819
C07K 5/1008
C07K 5/1019
C07K 5/1021
MCD-Hauptklasse MCM A61P 31/12 (2006.01)
MCD-Nebenklasse MCS A61K 38/05 (2006.01)
A61K 38/06 (2006.01)
A61K 38/07 (2006.01)
A61P 31/16 (2006.01)
C07K 5/072 (2006.01)
C07K 5/078 (2006.01)
C07K 5/083 (2006.01)
C07K 5/093 (2006.01)
C07K 5/09 (2006.01)
C07K 5/103 (2006.01)
C07K 5/113 (2006.01)
C07K 5/11 (2006.01)
MCD-Zusatzklasse MCA
57 Zusammenfassung AB [EN] The invention relates to the compound of general formula (I) as novel inhibitors of TMPRSS2 and their use for the prophylaxis and treatment of influenza virus infection or coronavirus infection, in particular, SARS-CoV2 (COVID-19) infection.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT WO002012162828A1
WO002016144654A1
56 Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt
CT
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
in Recherche ermittelt
CTNP ALEXANDER MAIWALD ET AL: "Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 31, no. sup1, 11 May 2016 (2016-05-11), GB, pages 89 - 97, XP055748134, ISSN: 1475-6366, DOI: 10.3109/14756366.2016.1172574 0;
COLOMBO ELOÏC ET AL: "Design and synthesis of potent, selective inhibitors of matriptase", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 3, no. 7, 12 July 2012 (2012-07-12), pages 530 - 534, XP008173043, ISSN: 1948-5875, [retrieved on 20120411], DOI: 10.1021/ML3000534 0;
DOMINIC DUCH?NE ET AL: "Analysis of Subpocket Selectivity and Identification of Potent Selective Inhibitors for Matriptase and Matriptase-2", JOURNAL OF MEDICINAL CHEMISTRY, VOL. 57, N.23, 11 November 2014 (2014-11-11), pages 10198 - 10204, XP055429365, Retrieved from the Internet [retrieved on 20171128], DOI: 10.1021/jm5015633 0;
HOFFMANN MARKUS ET AL: "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor", CELL, ELSEVIER, AMSTERDAM NL, vol. 181, no. 2, 5 March 2020 (2020-03-05), pages 271, XP086136225, ISSN: 0092-8674, [retrieved on 20200305], DOI: 10.1016/J.CELL.2020.02.052 0;
KWON HONGMOK ET AL: "Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors", BIORGANIC & MEDICINAL CHEMISTRY LETTERS,, vol. 26, no. 2, 8 December 2015 (2015-12-08), pages 310 - 314, XP029380287, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2015.12.023 0;
WILLIAM C RIPKA: "New thrombin inhibitors in cardiovascular disease", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 1, no. 2, 1 August 1997 (1997-08-01), GB, pages 242 - 253, XP055748161, ISSN: 1367-5931, DOI: 10.1016/S1367-5931(97)80016-6 0;
ZHENFU HAN ET AL: "Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 11, 10 October 2014 (2014-10-10), US, pages 1219 - 1224, XP055748199, ISSN: 1948-5875, DOI: 10.1021/ml500254r 0
56 Entgegengehaltene Nichtpatentliteratur/Zitate,
vom Anmelder genannt
CTNP ABEL T, BLOOD, vol. 122, 2013, pages 2030 - 2038 1;
DEMAISON C, HUM GENE THER., vol. 13, 2002, pages 803 - 813 1;
HOFFMANN ET AL., CELL, vol. 181, 2020, pages 271 - 280 1;
HURET JLAHMAD MARSABAN MBERNHEIM ACIGNA JDESANGLES FGUIGNARD JCJACQUEMOT-PERBAL MCLABARUSSIAS MLEBERRE V, NUCLEIC ACIDS RES., vol. 41, January 2013 (2013-01-01) 1;
KOUJI SAKAI ET AL., JOURNAL OF VIROLOGY, vol. 88, no. 10, 2014, pages 5608 - 5616 1;
MUNCH RC, MOL THER, vol. 19, 2011, pages 686 - 693 1;
ROMAIN ZUFFEREY, NAT. BIOTECHNOL., vol. 3, 1997, pages 3 - 8 1;
W-J SHIN ET AL., EXPERT OPINION ON DRUG DISCOVERY, vol. 12, no. 11, 2017, pages 1139 - 1152 1;
XIA S: "A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike", SCI ADV, vol. 5, 2019, pages eaav4580 1
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Sequenzprotokoll
Prüfstoff-IPC ICP A61P 31/12
A61P 31/16
C07K 5/072
C07K 5/078
C07K 5/083
C07K 5/093
C07K 5/09
C07K 5/103
C07K 5/113
C07K 5/11