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Document EP000002402433A1 (Pages: 25)

Bibliographic data Document EP000002402433A1 (Pages: 25)
INID Criterion Field Contents
54 Title TI [DE] Verfahren zur Erhöhung der Expression von rekombinanten Proteinen und Ausbeute von Plasmiden durch Kultivierung von eukaryotischen oder prokaryotichen Zellen in hohen Dichten
[EN] Method for increasing the expression of a recombinant protein and plasmid yield in an eukaryotic or prokaryotic high cell density culture
[FR] Méthode d'accroissement de l'expression d'une protéine recombinante et du rendement de plasmide à haute densité dans une culture d'eucaryote ou procaryote
71/73 Applicant/owner PA BIOSILTA OY, FI
72 Inventor IN NEUBAUER PETER, DE ; PILAREK MACIEJ, PL
22/96 Application date AD Jul 1, 2010
21 Application number AN 10168159
Country of application AC EP
Publication date PUB Jan 4, 2012
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31
32
Priority data PRC
PRN
PRD


51 IPC main class ICM C12N 1/38 (2006.01)
51 IPC secondary class ICS
IPC additional class ICA
IPC index class ICI
Cooperative patent classification CPC C12N 1/38
MCD main class MCM C12N 1/38 (2006.01)
MCD secondary class MCS
MCD additional class MCA
57 Abstract AB [EN] The present invention relates to a method for increasing the expression of a recombinant protein and plasmid yield in an eukaryotic or prokaryotic high cell density culture. The increase of the expression is achieved by the use of perfluorochemicals as ingredients of an enzyme-based fed-batch cultivation system by enhancing the cell growth rate and the final cell density.
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