| 54 |
Title |
TI |
[DE] Verfahren zur Herstellung von mineralisierten Kollagenfibrillen und deren Verwendung als Knochenersatzwerkstoff
[EN] Method for making mineralized collagen fibrils and their use as bone replacement material
[FR] Procédé de fabrication de fibrilles de collagène minéralisées et leur utilisation comme matériau de remplacement osseux |
| 71/73 |
Applicant/owner |
PA |
MERCK PATENT GMBH, DE
|
| 72 |
Inventor |
IN |
BRADT JENS, DE
;
JAMES W POLAREK, US
;
POMPE WOLFGANG PROF, DE
;
WEIS KARL DR, DE
|
| 22/96 |
Application date |
AD |
Mar 17, 1999 |
| 21 |
Application number |
AN |
99105435 |
|
Country of application |
AC |
EP |
|
Publication date |
PUB |
Sep 29, 1999 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
DE
19812713
19980324
|
| 51 |
IPC main class |
ICM |
A61L 27/00
|
| 51 |
IPC secondary class |
ICS |
C07K 1/00
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
A61L 27/425
C08L 89/06
D01F 1/10
D01F 4/00
|
|
MCD main class |
MCM |
A61L 27/00
(2006.01)
|
|
MCD secondary class |
MCS |
A61L 27/42
(2006.01)
A61L 27/46
(2006.01)
C07K 1/00
(2006.01)
C08L 89/06
(2006.01)
D01F 1/10
(2006.01)
D01F 4/00
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[DE] Die Erfindung betrifft ein Verfahren zur Herstellung von mineralisierten Kollagenfibrillen, wobei die Fibrillenbildung und Mineralisierung in einem Prozeßschritt ablaufen sowie deren Verwendung als Knochenersatzmaterial.
[EN] Mineralised collagen fibrils are produced by a one step fibril formation and mineralisation. Also, a collagen/calcium phosphate composite is manufactured by embedding the resulting fibrils in a calcium phosphate cement. Production of mineralised collagen fibrils comprises performing the fibril formation and mineralisation in one step. An Independent claim is also included for the manufacture of a collagen/calcium phosphate by embedding the produced mineralised collagen fibrils in a calcium phosphate cement consisting of calcium phosphates, e.g. tetracalcium phosphate, calcium hydrogen phosphate, calcium hydroxylapatite, calcium dihydrogen phosphate and/or calcium carbonate, sodium phosphates and/or their mixtures, using a collagen:CaP weight ratio of 1:1-200. |
| 56 |
Cited documents identified in the search |
CT |
|
| 56 |
Cited documents indicated by the applicant |
CT |
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
|
|
Citing documents |
|
Determine documents
|
|
Sequence listings |
|
|
|
Search file IPC |
ICP |
A61F 2/28
A61L 15/32
A61L 27/00
C07K 14/78 C
|
