| 54 |
Title |
TI |
[DE] Herstellung und Verwendung von Genbanken synthetischer menschlicher Antikörper ("synthetische Human-Anti-Körper-Bibliotheken)
[EN] Preparation and use of synthetic human antibody gene bank (synthetic human antibody libraries)
[FR] Préparation et utilisation de banques de gènes d'anticorps synthétiques humains (bibliothèques d'anticorps humains synthétiques) |
| 71/73 |
Applicant/owner |
PA |
BEHRINGWERKE AG, DE
|
| 72 |
Inventor |
IN |
BREITLING FRANK BERTHOLD, DE
;
DUEBEL STEFAN, DE
;
KLEWINGHAUS IRIS, DE
;
LITTLE MELVYN DR, DE
;
SEEHAUS THOMAS DR, DE
|
| 22/96 |
Application date |
AD |
Jan 28, 1991 |
| 21 |
Application number |
AN |
91101094 |
|
Country of application |
AC |
EP |
|
Publication date |
PUB |
Nov 20, 1996 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
DE
4002897
Feb 1, 1990
|
33
31
32 |
PRC
PRN
PRD |
DE
4003880
Feb 9, 1990
|
| 51 |
IPC main class |
ICM |
C12N 15/13
|
| 51 |
IPC secondary class |
ICS |
C07K 16/00
C12P 21/08
G01N 33/53
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
C07K 16/00
C07K 16/44
C07K 2319/00
C07K 2319/02
C07K 2319/033
C07K 7/06
C12N 15/1093
C12N 15/11
C12N 15/625
C12N 15/65
C12N 15/70
C12N 9/88
|
|
MCD main class |
MCM |
C07H 21/04
(2006.01)
|
|
MCD secondary class |
MCS |
C07K 14/00
(2006.01)
C07K 16/00
(2006.01)
C07K 16/44
(2006.01)
C07K 7/06
(2006.01)
C12N 15/09
(2006.01)
C12N 15/10
(2006.01)
C12N 15/13
(2006.01)
C12N 15/62
(2006.01)
C12N 15/65
(2006.01)
C12N 15/70
(2006.01)
C12N 5/10
(2006.01)
C12N 9/88
(2006.01)
C12P 21/08
(2006.01)
G01N 33/53
(2006.01)
|
|
MCD additional class |
MCA |
C12R 1/19
(2006.01)
|
| 57 |
Abstract |
AB |
[EN] Synthetic human antibody libraries are constructed by'generation of random sequences for the hypervariable regions under the restrictions (a) or (e), batch A or batch B according to Table 1 and subsequent insertion into an expression vector' (sic). Synthetic human antibody libraries can be produced by using almost randomly synthesised oligonucleotides coding for each of the three hypervariable regions in the variable parts of the heavy and light chains (regions CDR1, CDR2 and CDR3). |
| 56 |
Cited documents identified in the search |
CT |
|
| 56 |
Cited documents indicated by the applicant |
CT |
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
|
|
Citing documents |
|
Determine documents
|
|
Sequence listings |
|
|
|
Search file IPC |
ICP |
|
