| 54 |
Title |
TI |
[DE] Nanopartikel zur selektiven Gewebetherapie, Verfahren zu deren Herstellung und deren Verwendung in der Gewebetherapie
[EN] Nanoparticle comprising piezoelectric, pyroelectric or ferroelectric crystalline core material with electric dipole properties, useful as an agent for selective tissue therapy |
| 71/73 |
Applicant/owner |
PA |
Technische Universität Dresden, 01069 Dresden, DE
|
| 72 |
Inventor |
IN |
|
| 22/96 |
Application date |
AD |
May 8, 2008 |
| 21 |
Application number |
AN |
102008023228 |
|
Country of application |
AC |
DE |
|
Publication date |
PUB |
Nov 19, 2009 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
|
| 51 |
IPC main class |
ICM |
B82B 1/00
(2006.01)
|
| 51 |
IPC secondary class |
ICS |
A61K 9/18
(2006.01)
A61K 9/51
(2006.01)
B82B 3/00
(2006.01)
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
A61K 47/60
A61K 47/68
A61K 47/6923
A61K 47/6929
A61K 9/0009
A61K 9/5115
B82Y 5/00
|
|
MCD main class |
MCM |
B82B 1/00
(2006.01)
|
|
MCD secondary class |
MCS |
A61K 9/18
(2006.01)
A61K 9/51
(2006.01)
B82B 3/00
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[DE] Die Erfindung betrifft Nanopartikel, geeignet zur selektiven Gewebetherapie, aufweisend ein piezoelektrisches, pyroelektrisches oder ferroelektrisches kristallines Kernmaterial mit elektrischen Dipoleigenschaften, dadurch gekennzeichnet, dass die Oberfläche des kristallinen Kernmaterials eine ladungsneutralisierende Adsorbatschicht aus molekularen und/oder ionischen Spezies aufweist, die ganz oder teilweise von der Oberfläche ablösbar ist und somit die Dipoleigenschaften der Nanopartikel selektiv im Gewebe aktivierbar und damit die Nanopartikel chemisch oder biologisch wirksam sind. Ein Verfahren zur Herstellung der Nanopartikel und deren Verwendung ist beschrieben.
[EN] Nanoparticle comprising piezoelectric, pyroelectric or ferroelectric crystalline core material with electric dipole properties, is claimed, where: the surface of the crystalline core material exhibits charge neutralizing adsorbate layers made of molecular and/or ionic species; the adsorbate layer is completely or partially detachable from the surface; and the dipole properties of the nanoparticles are selectively activated in the tissue and the nanoparticles are chemically or biologically effective. An independent claim is included for a method for producing nanoparticles comprising providing and contacting charge-neutralizing molecules and/or ionic species in an atmosphere or solution for the formation of an adsorbate layer on the surface of the crystalline core materials, and adjusting the adsorbed layer to be completely or partially separable by an external action to induce chemical or biological effect, where the core material is selected with a dimension of the sub-micro meter range. ACTIVITY : None given. MECHANISM OF ACTION : None given. |
| 56 |
Cited documents identified in the search |
CT |
DE102006046078A1
US000007273904B2
WO002006124670A2
|
| 56 |
Cited documents indicated by the applicant |
CT |
DE102006016430A1
DE000019726766A1
DE102007053076A1
EP000001450751A2
EP000001747039A2
EP000001818046A1
EP000001819277A1
US000004483756A
US000005304382A
US000005358722A
US000005569388A
US000005599455A
US000005690903A
US000005770089A
US000005776346A
US000006034013A
US000006308356B1
US000007264735B2
WO002003018006A1
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
Srinivas Ganta [u.a.]: "A review of stimuli-responsive nanocarriers for drug and gene delivery". Journal of Controlled Release 126, pp. 187-204 (March 2008) p 0;
Jinping Liu [u.a.]: "Preparation and photoluminescence of ZnO complex structures with controlled morphology". Materials Letters 60, pp. 1354-1359 (2006) p 0;
Shengcong Liufu [u.a.]: "Investigation of PEG adsorption on the surface of zinc oxide nanoparticles". Power Technology 145, pp. 20-24 (2004) p 0
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
Blake et al. Separation And Purification Methods 28, 1-50 (1999) 1;
Ganta, S. et al. 2008 1;
Ganta, S., Devalapally, H., Shahiwala, A., Amiji, M., A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control Release. 2008 Mar 20; 126(3): 187-204 1;
Jordan, A., Maier-Hauff, K., Wust, R., Rau, B., Johannsen, M., Thermotherapy using magnetic nanoparticles. ONKOLOGE. 13 (10) 896-902 1;
Ni, H. et al, 2007 1;
Vaupel, P., Kallinowski, F., Okunieff, P., Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 1989 Dec 1; 49(23): 6449-6465 1;
Vijayaraghavalu, S., Raghavan, D., Labhasetwar, V., Nanoparticles for delivery of chemotherapeutic agents to tumors. Curr Opin Investig Drugs. 2007 Jun; 8(6): 477-484 1;
Xia, Process Biochemistry 41, 221-225 (2006) 1
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