| 54 |
Title |
TI |
[DE] Verfahren und Vorrichtung zur Be- und Entgasung von Flüssigkeiten
[EN] Procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component |
| 71/73 |
Applicant/owner |
PA |
Bayer Technology Services GmbH, 51373 Leverkusen, DE
|
| 72 |
Inventor |
IN |
Brod, Helmut, Dr.-Ing., 51061 Köln, DE
;
Frahm, Björn, Dr.-Ing., 40699 Erkrath, DE
;
Kauling, Jörg, Dipl.-Ing., 51069 Köln, DE
;
Rose, Reinhold, 51371 Leverkusen, DE
|
| 22/96 |
Application date |
AD |
Feb 24, 2006 |
| 21 |
Application number |
AN |
102006008687 |
|
Country of application |
AC |
DE |
|
Publication date |
PUB |
Aug 30, 2007 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
|
| 51 |
IPC main class |
ICM |
C12M 1/04
(2006.01)
|
| 51 |
IPC secondary class |
ICS |
C12M 1/06
(2006.01)
C12M 1/12
(2006.01)
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
B01F 23/20
B01F 23/23124
B01F 23/231244
B01F 23/231265
B01F 23/2373
B01F 31/00
B01F 31/445
C12M 1/06
C12M 1/12
C12M 23/24
C12M 27/20
C12M 29/04
C12M 29/20
C12M 41/34
C12M 41/40
|
|
MCD main class |
MCM |
B01F 33/40
(2022.01)
C12M 1/04
(2006.01)
|
|
MCD secondary class |
MCS |
C12M 1/06
(2006.01)
C12M 1/12
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[DE] Die Erfindung betrifft ein Verfahren und eine Vorrichtung zur blasenfreien Begasung von Flüssigkeiten, insbesondere in der Biotechnologie und speziell von Zellkulturen.
[EN] The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude and the equivalent number of revolutions. The procedure for gassing of liquid for cell cultures, comprises exchanging of gas over immersed membrane surfaces like hoses, cylinders or modules, and controlling the gassing rate change of the gas concentration and/or pressure of the gas or gas mixture or gas component flowing into/out of the area within the membrane surface. The membrane surface represents any rotatingly oscillating movement in the liquid. The gassing rate, transfer efficiency, mixing time and/or shear stress are controlled by change of the movement like amplitude, the equivalent number of revolutions, acceleration of the membrane surface, the delay of the membrane surface, the interruption of the movement or discontinuity. The course of motion is not restricted to recurring samples. The material transfer is increased by mounting of immovable current interfering elements. The disturb of the current forms by the rotatingly oscillating movement of the membrane surfaces. The supply of the membrane surface is undertaken with the help of flexible hoses or turning seals for the supply and discharge of gas. The membrane surface is used for the production of micro-bubbles or gas bubbles in the liquid. Rotor arms rotate in one of the rotation directions curved around the drive shaft. An independent claim is included for a device for gassing of liquid for cell cultures. |
| 56 |
Cited documents identified in the search |
CT |
|
| 56 |
Cited documents indicated by the applicant |
CT |
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
|
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Citing documents |
|
Determine documents
|
|
Sequence listings |
|
|
|
Search file IPC |
ICP |
C12M 1/04
C12M 1/06
C12M 1/12
|
