| 54 |
Title |
TI |
[EN] SLIPPERY MICROPROPELLERS PENETRATE THE VITREOUS HUMOR |
| 71/73 |
Applicant/owner |
PA |
MAX PLANCK INNOVATION GMBH, DE
|
| 72 |
Inventor |
IN |
FISCHER PEER, DE
;
QIU TIAN, DE
;
WU ZHIGUANG, DE
|
| 22/96 |
Application date |
AD |
Aug 21, 2018 |
| 21 |
Application number |
AN |
201816641059 |
|
Country of application |
AC |
US |
|
Publication date |
PUB |
Jun 10, 2021 |
33
31
32 |
Priority data |
PRC
PRN
PRD |
EP
2018072501
Aug 21, 2018
|
33
31
32 |
PRC
PRN
PRD |
EP
17187924
Aug 25, 2017
|
| 51 |
IPC main class |
ICM |
A61K 49/18
(2006.01)
|
| 51 |
IPC secondary class |
ICS |
A61K 41/00
(2020.01)
A61K 45/06
(2006.01)
A61K 9/00
(2006.01)
|
|
IPC additional class |
ICA |
|
|
IPC index class |
ICI |
|
|
Cooperative patent classification |
CPC |
A61F 9/0017
A61K 41/00
A61K 45/06
A61K 49/1824
A61K 9/0009
A61K 9/0051
A61K 9/0085
B82Y 25/00
B82Y 5/00
|
|
MCD main class |
MCM |
A61K 49/18
(2006.01)
|
|
MCD secondary class |
MCS |
A61K 41/00
(2020.01)
A61K 45/06
(2006.01)
A61K 9/00
(2006.01)
|
|
MCD additional class |
MCA |
|
| 57 |
Abstract |
AB |
[EN] Microparticles actively propel through the vitreous humour and reach the retina in porcine eyes. The slippery micro helical propellers are constructed by the combination of glancing angle deposition technique and the fusion of the slippery liquid layer. The magnetically propulsion in the vitreous humour relies on the matched size of the propeller to the collagen network of the vitreous, and the anti-adhesion coating of the collagen fiber bundles. Clinical optical coherence tomography observed the displacement of the slippery micropropellers through the vitreous to the macular area on the retina. The slippery micropropellers realize the controllable massive movements to the retina in 30 mins, while exerting the travelling distance of above one centimeter. The injection of the slippery micropropellers, the magnetically-powered controllable propulsion in the vitreous, and the optical coherence tomography imaging technique, constitute an intact method for rapid targeted ocular delivery, providing a promising approach towards ophthalmologic applications. |
| 56 |
Cited documents identified in the search |
CT |
US020190247525A1
|
| 56 |
Cited documents indicated by the applicant |
CT |
|
| 56 |
Cited non-patent literature identified in the search |
CTNP |
|
| 56 |
Cited non-patent literature indicated by the applicant |
CTNP |
|
|
Citing documents |
|
Determine documents
|
|
Sequence listings |
|
|
|
Search file IPC |
ICP |
A61F 9/00
A61K 41/00
A61K 49/18
A61K 9/00
B82Y 25/00
B82Y 5/00
|
