Bibliografische Daten

Dokument WO002011029696A1 (Seiten: 47)

Bibliografische Daten Dokument WO002011029696A1 (Seiten: 47)
INID Kriterium Feld Inhalt
54 Titel TI [EN] DIRECTED EVOLUTION OF ARGININE DEIMINASE FOR INCREASED ACTIVITY AT PHYSIOLOGICAL PH
[FR] ÉVOLUTION DIRIGÉE DE L'ARGININE DÉSIMINASE POUR UNE ACTIVITÉ ACCRUE AU PH PHYSIOLOGIQUE
71/73 Anmelder/Inhaber PA RWTH AACHEN UNIVERSITY, DE ; SCHWANEBERG ULRICH, BE ; UNIV JACOBS BREMEN GMBH, DE ; ZHU LEILEI, DE
72 Erfinder IN SCHWANEBERG ULRICH, BE ; ZHU LEILEI, DE
22/96 Anmeldedatum AD 16.08.2010
21 Anmeldenummer AN 2010061884
Anmeldeland AC EP
Veröffentlichungsdatum PUB 17.03.2011
33
31
32
Priorität PRC
PRN
PRD
EP
09011729
20090914
51 IPC-Hauptklasse ICM C12N 9/78 (2006.01)
51 IPC-Nebenklasse ICS C12N 15/55 (2006.01)
IPC-Zusatzklasse ICA A61K 38/50 (2006.01)
A61P 35/00 (2006.01)
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC A61K 38/00
A61P 35/00
C12N 9/78
C12Y 305/03006
MCD-Hauptklasse MCM C12N 9/78 (2006.01)
MCD-Nebenklasse MCS C12N 15/55 (2006.01)
MCD-Zusatzklasse MCA A61K 38/50 (2006.01)
A61P 35/00 (2006.01)
57 Zusammenfassung AB [EN] The present invention relates to modified arginine deiminases exhibiting an increased activity and/or reduced Km value at a higher pH, compared to a non-modified arginine deiminase, as well as uses of these enzymes for the treatment of cancer and unwanted tumor-induced neovascularization in a cancer. The present invention further relates to a method for modifying the pH optimum of the activity of an arginine deiminase, wherein said modifying provides an increased activity of said modified arginine deiminase at a higher pH, compared to a non-modified arginine deiminase.
[FR] La présente invention porte sur des arginines désiminase modifiées présentant une activité accrue et/ou une valeur de Km réduite à un pH plus élevé, par comparaison avec une arginine désiminase non modifiée, ainsi que sur des utilisations de ces enzymes pour le traitement d'un cancer et d'une néovascularisation induite par une tumeur non souhaitée dans un cancer. La présente invention porte en outre sur un procédé de modification de l'optimum de pH de l'activité d'une arginine désiminase, ladite modification fournissant une activité accrue de ladite arginine désiminase modifiée à un pH plus élevé, par comparaison avec une arginine désiminase non modifiée.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT
56 Entgegengehaltene Patentdokumente/Zitate,
vom Anmelder genannt
CT US000005474928A
WO001998033519A1
WO001998051784A1
WO002001083774A2
WO002008141523A1
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Sequenzprotokoll
Prüfstoff-IPC ICP A61K 38/50
A61P 35/00
C12N 15/55
C12N 9/78