56 |
Entgegengehaltene Nichtpatentliteratur/Zitate, vom Anmelder genannt |
CTNP |
"National Cancer Institute , Division of Cancer Treatment; Taxol. IND 22850. NSC 125973", CLINICAL BROCHURE, 1992, pages 26 - 27 1; ADVANI R ET AL.: "Phase I study of BMS 188797, a new taxane analog administered weekly in patients with advanced malignancies.", PROCEEDINGS OF ASCO, vol. 20, 2001, pages 422 1; ALI SM ET AL.: "Butitaxel analogues: synthesis and structure-activity relationships", J MED CHEM., vol. 40, no. 2, 17 January 1997 (1997-01-17), pages 236 - 41 1; ALI, S. M. ET AL.: "Butitaxel analogues: synthesis and structure- activity relationships", J MED CHEM, vol. 40, 1997, pages 236 - 241 1; ALTSTADT, T. J. ET AL.: "Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476", J MED CHEM, vol. 44, 2001, pages 4577 - 4583, XP002207316, DOI: doi:10.1021/jm0102607 1; ANTRI M; ORSAL D.; BARTHE JY., EUR J NEUROSCI., vol. 16, 2002, pages 467 - 476 1; ARGARANA, C. E.; BARRA, H. S.; CAPUTTO, R: "Release of [14C]tyrosine from tubulinyl-[14C]tyrosine by brain extract. Separation of a carboxypeptidase from tubulin-tyrosine ligase", MOL CELL BIOCHEM, vol. 19, 1978, pages 17 - 21 1; BAREYRE F. M. ET AL., NAT NEUROSCI, vol. 7, 2004, pages 269 - 277 1; BASSO D. M.; BEATTIE M. S.; BRESNAHAN J. C., J NEUROTRAUMA, vol. 12, 1995, pages 1 - 21 1; BEGLEITER A ET AL.: "Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo", BR J CANCER, vol. 91, no. 8, 18 October 2004 (2004-10-18), pages 1624 - 31 1; BIOCHEMISTRY, vol. 38, pages 5490 - 5498 1; BISSERY, M. C.: "Preclinical evaluation of new taxoids", CURR PHARM DES, vol. 7, 2001, pages 1251 - 1257, XP008010623, DOI: doi:10.2174/1381612013397465 1; BITO H. ET AL., NEURON, vol. 26, 2000, pages 431 - 441 1; BOCCA, C ET AL.: "Microtubule- interacting activity and cytotoxicity of the prenylated coumarin ferulenol", PLANTA MED, vol. 68, 2002, pages 1135 - 1137 1; BOCCA, C. ET AL.: "A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells", CHEM BIOL INTERACT, vol. 147, 2004, pages 79 - 86 1; BOLLAG, D. M ET AL.: "Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action", CANCER RES, vol. 55, 1995, pages 2325 - 2333, XP002111282 1; BORISOFF J. F. ET AL., MOL CELL NEUROSCI., vol. 22, 2003, pages 405 - 416 1; BRADBURY E. J., NATURE, vol. 416, 2002, pages 636 - 640 1; BRADKE F.; DOTTI C. G., CURR BIOL, vol. 10, 2000, pages 1467 - 1470 1; BRADKE F.; DOTTI C. G., SCIENCE, vol. 283, 1999, pages 1931 - 1934 1; BRADKE, F.; DOTTI, C. G.: "Neuronal Polarity: Vectorial Cytoplasmic Flow Precedes Axon Formation", NEURON, vol. 19, 1997, pages 1175 - 1186 1; BRADKE, F.; DOTTI, C. G.: "The role of local actin instability in axon formation", SCIENCE, vol. 283, 1999, pages 1931 - 1934, XP002206674, DOI: doi:10.1126/science.283.5409.1931 1; BRADLEY MO ET AL.: "Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel", CLIN CANCER RES., vol. 7, no. 10, October 2001 (2001-10-01), pages 3229 - 38, XP002272095 1; BRADLEY, M. O. ET AL.: "Tumor targeting by conjugation of DHA to paclitaxel", J CONTROL RELEASE, vol. 74, 2001, pages 233 - 236, XP004297528, DOI: doi:10.1016/S0168-3659(01)00321-2 1; BRADLEY, M. O. ET AL.: "Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel", CLIN CANCER RES, vol. 7, 2001, pages 3229 - 3238, XP002272095 1; BUCK, K. B.; ZHENG, J. Q.: "Growth cone turning induced by direct local modification of microtubule dynamics", J NEUROSCI, vol. 22, 2002, pages 9358 - 67 1; BUCK, K. B.; ZHENG, J. Q.: "Growth cone turning induced by direct local modification of microtubule dynamics", J NEUROSCI, vol. 22, 2002, pages 9358 - 9367 1; BUCK, K. B; ZHENG, J. Q.: "Growth cone turning induced by direct local modification of microtubule dynamics", J NEUROSCI, vol. 22, 2002, pages 9358 - 9367 1; BURLINGAME, M. A. ET AL., BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 2335 - 2338 1; CAMPS C ET AL.: "Phase II trial of the novel taxane BMS-184476 as second-line in non-small- cell lung cancer.", ANN ONCOL., 31 January 2005 (2005-01-31) 1; CANCER RES, vol. 61, pages 5499 - 5504 1; CARBONI, J. M. ET AL.: "Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules", J MED CHEM, vol. 36, 1993, pages 513 - 515, XP001026028, DOI: doi:10.1021/jm00056a013 1; CARONI P.; SCHWAB M. E., J CELL BIOL, vol. 106, 1988, pages 1281 - 1288 1; CHOU TC ET AL.: "Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state", ANGEW CHEM INT ED ENGL., vol. 42, no. 39, 13 October 2003 (2003-10-13), pages 4762 - 7, XP002578751, DOI: doi:10.1002/ANIE.200352361 1; CHOU TC ET AL.: "Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxe l", PROC NATL ACAD SCI U S A., vol. 95, no. 26, 22 December 1998 (1998-12-22), pages 15798 - 802, XP002254264, DOI: doi:10.1073/pnas.95.26.15798 1; CHOU TC ET AL.: "The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice.", PROC NATL ACAD SCI USA., vol. 98, no. 14, 3 July 2001 (2001-07-03), pages 8113 - 8, XP002982641, DOI: doi:10.1073/pnas.131153098 1; CHOU, T. C. ET AL.: "Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state", ANGEW CHEM INT ED ENGL, vol. 42, 2003, pages 4762 - 4767 1; CHOU, T. C. ET AL.: "Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.", PROC NATL ACAD SCI U S A, vol. 95, 1998, pages 15798 - 15802, XP002254264, DOI: doi:10.1073/pnas.95.26.15798 1; CHOU, T. C. ET AL.: "Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B", PROC NATL ACAD SCI U S A, vol. 95, 1998, pages 9642 - 9647, XP002189846, DOI: doi:10.1073/pnas.95.16.9642 1; CHOU, T. C. ET AL.: "The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice", PROC NATL ACAD SCI U S A, vol. 98, 2001, pages 8113 - 8118, XP002982641, DOI: doi:10.1073/pnas.131153098 1; CHOY, N. ET AL., J . MED. CHEM., vol. 46, 2003, pages 2846 - 2864 1; CINEL, B. ET AL.: "Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization", ORG LETT, vol. 2, 2000, pages 257 - 260, XP002159667, DOI: doi:10.1021/ol9912027 1; CISTERNINO, S. ET AL.: "Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats.", BR J PHARMACOL, vol. 138, 2003, pages 1367 - 1375, XP055020435, DOI: doi:10.1038/sj.bjp.0705150 1; CURRAN, D. P.; FURUKAWA, T., ORG. LETT., vol. 4, 2002, pages 22 33 - 2235 1; CURRY EA 3RD ET AL.: "Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer", INVEST NEW DRUGS, vol. 22, no. 3, August 2004 (2004-08-01), pages 299 - 305, XP019206057, DOI: doi:10.1023/B:DRUG.0000026256.38560.be 1; DA SILVA, J. S.; DOTTI, C. G.: "Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis", NAT REV NEUROSCI, vol. 3, 2002, pages 694 - 704 1; DAVID, B. ET AL.: "Rhazinilam mimics the cellular effects of taxol by different mechanisms of action", CELL MOTIL CYTOSKELETON, vol. 28, 1994, pages 317 - 326, XP008031958, DOI: doi:10.1002/cm.970280405 1; DAVID, B. ET AL.: "Rhazinilam mimics the cellular effects of taxol by different mechanisms of action.", CELL MOTIL CYTOSKELETON, vol. 28, 1994, pages 317 - 326, XP008031958, DOI: doi:10.1002/cm.970280405 1; DE HOOP, M. J: "IN CELL BIOLOGY: A LABORATORY HANDBOOK", 1998, ACADEMIC PRESS, article "Culturing hippocampal neurons and astrocytes from fetal rodent brain", pages: 154 - 163 1; DENT E.W.; GERTLER F.B., NEURON, vol. 40, 2003, pages 209 - 227 1; DERGHAM P ET AL., J NEUROSCI., vol. 22, 2002, pages 6570 - 6577 1; DIETZMANN, A. ET AL.: "Nanomolar concentrations of epothilone D inhibit the proliferation of glioma cells and severely affect their tubulin cytoskeleton", J NEUROONCOL, vol. 65, 2003, pages 99 - 106 1; DOTTI, C, J. NEUROSCI., vol. 8, 1988, pages 1454 - 68 1; DOTTI, CG; BANKER, NATURE, vol. 330, 1987, pages 254 - 6 1; ENG C ET AL.: "A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer", ANN ONCOL, vol. 15, no. 6, June 2004 (2004-06-01), pages 928 - 32, XP008060117, DOI: doi:10.1093/annonc/mdh236 1; ETIENNE-MANNEVILLE S; HALL A, NATURE, vol. 420, 2002, pages 629 - 635 1; FOURNIER A.E.; TAKIZAWA B. T.; STRITTMATTER S.M., J NEUROSCI., vol. 23, 2003, pages 1416 - 1423 1; FRAIGUI O; LAMNAOUER D; FAOUZI MY: "Acute toxicity of ferulenol, a 4- hydroxycoumarin isolated from Ferula communis L.", VET HUM TOXICOL., vol. 44, no. 1, February 2002 (2002-02-01), pages 5 - 7, XP009178035 1; FUMOLEAU P ET AL.: "Phase I and pharmacokinetic (PK) study of RPR 116258A, given as a weekly 1-hour infusion at day 1, day 8, day 15, day 22 every 5 weeks in patients (pts) with advanced solid tumors", PROCEEDINGS OF THE 2001 AACR- NCI-EORTC INTERNATIONAL CONFERENCE, vol. 282, pages 58 1; FUMOLEAU, P. ET AL.: "Phase I and pharmacokinetic (PK) study of RPR 116258A, given as a weekly 1-hour infusion at day 1, day 8, day 15, day 22 every 5 weeks in patients (pts) with advanced solid tumors", PROCEEDINGS OF THE 2001 AACR-NCI-EORTC INTERNATIONAL CONFERENCE RÉSUMÉ, vol. 282, 2001, pages 58 1; GOETZ AD ET AL.: "Phase I and pharmacokinetic study of RPR 116258A, a novel taxane derivative, administered intravenously over 1 hour every 3 weeks", PROCEEDINGS OF ASCO, vol. 20, no. 419, 2001, pages 106A 1; GOETZ, A. D. ET AL.: "Phase I and pharmacokinetic study of RPR 116258A, a novel taxane derivative, administered intravenously over 1 hour every 3 weeks", PROCEEDINGS OF ASCO 2 0, vol. 419, 2001, pages 106A 1; GOODIN, S.; KANE, M. P.; RUBIN, E. H.: "Epothilones: mechanism of action and biologic activity", J CLIN ONCOL, vol. 22, 2004, pages 2015 - 2025, XP008039858, DOI: doi:10.1200/JCO.2004.12.001 1; GORDON-WEEKS, P. R.: "Microtubules and growth cone function", J NEUROBIOL, vol. 58, 2004, pages 70 - 83 1; GOSLIN, K.; BANKER, G.: "IN CULTURING NERVE CELLS", 1991, MIT PRESS, article "Rat hippocampal neurons in low-density culture", pages: 251 - 281 1; GUERITTE-VOEGELEIN F ET AL.: "Relationships between the structure of taxol analogues and their antimitotic activity", J MED CHEM., vol. 34, no. 3, March 1991 (1991-03-01), pages 992 - 8, XP002350804, DOI: doi:10.1021/jm00107a017 1; GUNASEKERA, S. P. ET AL., J. NAT. PROD., vol. 6, 2002, pages 1643 - 1648 1; GUNASEKERA, S. P. ET AL., J. NAT. PROD., vol. 67, 2004, pages 749 - 756 1; GUNASEKERA, S. P.; LONGLEY, R. E.; ISBRUCKER, R. A., J. NAT. PROD., vol. 64, 2001, pages 171 - 174 1; GUNASEKERA, S. P.; LONGLEY, R. E.; ISBRUCKER, R. A., J. NAT. PROD., vol. 65, 2002, pages 1830 - 1837 1; HAGGARTY, S. J. ET AL.: "Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis", CHEM BIOL, vol. 7, 2000, pages 275 - 286, XP055032557, DOI: doi:10.1016/S1074-5521(00)00101-0 1; HAMEL, E. ET AL.: "The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule- associated proteins and binding at the polymer taxoid site", BIOCHEMISTRY, vol. 38, 1999, pages 5490 - 5498, XP001088072, DOI: doi:10.1021/bi983023n 1; HELLER JD ET AL.: "Tetra-O-methyl nordihydroguaiaretic acid induces G2 arrest in mammalian cells and exhibits tumoricidal activity in vivo", CANCER RES., vol. 61, no. 14, 15 July 2001 (2001-07-15), pages 5499 - 504 1; HERMANNS, S., J. NEUROSCI. METHODS, vol. 110, 2001, pages 141 - 146 1; HIDALGO M ET AL.: "Phase I and pharmacokinetic study of BMS 184476, a taxane with greater potency and solubility than paclitaxel.", J CLIN ONCOL, vol. 19, 2001, pages 2493 - 503 1; HOOD, K. A. ET AL.: "Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity", CANCER RES, vol. 62, 2002, pages 3356 - 3360 1; HUNG, D. T.; CHEN, J.; SCHREIBER, S. L.: "Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest", CHEM BIOL, vol. 3, 1996, pages 287 - 293, XP026897128, DOI: doi:10.1016/S1074-5521(96)90108-8 1; HUNG, D. T.; NERENBERG, J. B.; SCHREIBER, S. L., CHEM. BIOL., vol. 1, 1994, pages 6 7 - 71 1; HUNG, D. T.; NERENBERG, J. B.; SCHREIBER, S. L., J. AM. CHEM. SOC., vol. 118, 1996, pages 11054 - 11080 1; ISBRUCKER, R. A.; GUNASEKERA, S. P.; LONGLEY, R. E., CANCER CHEMOTHER. PHARMACOL., vol. 48, 2001, pages 29 - 36 1; ISHII K. ET AL., J NEUROSCI RES, vol. 65, 2001, pages 500 - 507 1; JAFFE JJ; DOREMUS HM; MEYMARIAN E: "Activity of tubercidin against immature Fasciola hepatica in mice", J PARASITOL., vol. 62, no. 6, December 1976 (1976-12-01), pages 910 - 3 1; KAVALLARIS, M.; VERRILLS, N. M.; HILL, B. T.: "Anticancer therapy with novel tubulin-interacting drugs", DRUG RESIST UPDAT, vol. 4, 2001, pages 392 - 401, XP009021226, DOI: doi:10.1054/drup.2002.0230 1; KIM J. E. ET AL., NEURON, vol. 44, 2004, pages 439 - 451 1; KIM TY ET AL.: "Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies", CLIN CANCER RES., vol. 10, no. 11, 1 June 2004 (2004-06-01), pages 3708 - 16 1; KIM, T. Y. ET AL.: "Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies.", CLIN CANCER RES, vol. 10, 2004, pages 3708 - 3716 1; KLAR, U. ET AL.: "New synthetic inhibitors of microtubule depolymerization", BIOORG MED CHEM LETT, 1998, pages 1397 - 1402, XP004137211, DOI: doi:10.1016/S0960-894X(98)00226-1 1; KLAR, U. ET AL.: "New synthetic inhibitors of microtubule depolymerization", BIOORG MED CHEM LETT, vol. 8, 1998, pages 1397 - 1402, XP004137211, DOI: doi:10.1016/S0960-894X(98)00226-1 1; KOSHKINA NV ET AL.: "Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model", CLIN CANCER RES., vol. 7, no. 10, October 2001 (2001-10-01), pages 3258 - 62, XP055132338 1; KOSHKINA, N. V. ET AL.: "Paclitaxel liposome aerosol treatment induces inhibition of pulmonary metastases in murine renal carcinoma model", CLIN CANCER RES, vol. 7, 2001, pages 3258 - 3262, XP055132338 1; KOWALSKI, R. J. ET AL.: "The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells", MOL PHARMACOL, vol. 52, 1997, pages 613 - 622, XP000991361 1; KOWALSKI, R. J.; GIANNAKAKOU, P.; HAMEL, E.: "Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R", J BIOL CHEM, vol. 272, 1997, pages 2534 - 2541, XP002111279, DOI: doi:10.1074/jbc.272.4.2534 1; KULKE MH ET AL.: "A phase II study of docetaxel in patients with metastatic carcinoid tumors.", CANCER INVEST, vol. 22, no. 3, 2004, pages 353 - 9 1; KURATA T ET AL.: "Phase I and pharmacokinetic study of a new taxoid, RPR 109881A, given as a 1-hour infusion in patients with advanced solid tumors.", J CLIN ONCOL, vol. 18, 2000, pages 3164 - 71, XP008010639 1; KURATA, T. ET AL.: "Phase I and pharmacokinetic study of a new taxoid, RPR 109881A, given as a 1-hour intravenous infusion in patients with advanced solid tumors", J CLIN ONCOL, vol. 18, 2000, pages 3164 - 3171, XP008010639 1; LANGER CJ: "CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes", CLIN LUNG CANCER, vol. 6, no. 2, December 2004 (2004-12-01), pages 85 - 8 1; LANGER, C. J.: "CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes", CLIN LUNG CANCER, vol. 6, no. 2, 2004, pages 85 - 88 1; LEE Y. S. ET AL., J NEUROPATHOL EXP NEUROL., vol. 63, 2004, pages 233 - 245 1; LEHMANN M. ET AL., J NEUROSCI., vol. 19, 1999, pages 7537 - 7547 1; LEUNG, S. Y. ET AL.: "Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors", PROSTATE, vol. 44, 2000, pages 156 - 163, XP000961440, DOI: doi:10.1002/1097-0045(20000701)44:2<156::AID-PROS8>3.0.CO;2-8 1; LI M. ET AL., J NEUROSCI RES., vol. 46, 1996, pages 404 - 414 1; LI, C. ET AL.: "Biodistribution of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in mice with ovarian OCa-1 tumor", CANCER CHEMOTHER PHARMACOL, vol. 46, 2000, pages 416 - 422, XP001023466, DOI: doi:10.1007/s002800000168 1; LI, C. ET AL.: "Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate", CANCER RES, vol. 58, 1998, pages 2404 - 2409, XP000986297 1; LIMURA S ET AL.: "Orally active docetaxel analogue: synthesis of 10- deoxy-10-C-morpholinoethyl docetaxel analogues", BIOORG MED CHEM LETT., vol. 11, no. 3, 12 February 2001 (2001-02-12), pages 407 - 10 1; LIMURA, S. ET AL.: "Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues", BIOORG MED CHEM LETT, vol. 11, 2001, pages 407 - 410 1; LINDEL, T. ET AL.: "Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules", J AM CHEM SOC, vol. 119, 1997, pages 8744 - 8745, XP002093405, DOI: doi:10.1021/ja9717828 1; LONG, B. H. ET AL.: "Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol", CANCER RES, vol. 58, 1998, pages 1111 - 1115 1; LORTHORALY A ET AL.: "Phase I and pharmacokinetic (PK) study of RPR 116258A given as a 1-hour infusion in patients (pts) with advanced solid tumors", PROCEEDINGS OF THE 11TH NCI-EORTC-AACR SYMPOSIUM, vol. 569, 2000, pages 156 - 7 1; LORTHORALY, A. ET AL.: "Phase I and pharmacokinetic (PK) study of RPR 116258A given as a 1-hour infusion in patients (pts) with advanced solid tumors", PROCEEDINGS OF THE 11TH NCI-EORTC-AACR SYMPOSIUM 2000, vol. 569, 2000, pages 156 - 157 1; LUO L., NAT REV NEUROSCI, vol. 1, 2000, pages 173 - 180 1; MADARI, H. ET AL.: "Dicoumarol: a unique microtubule stabilizing natural product that is synergistic with Taxol", CANCER RES, vol. 63, 2003, pages 1214 - 1220 1; MARTELLO, L. A. ET AL., CHEM. BIOL., vol. 8, 2001, pages 8 43 - 855 1; MARTELLO, L. A. ET AL.: "Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines", CLIN CANCER RES, vol. 6, 2000, pages 1978 - 1987 1; MATSUDA H ET AL.: "Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood- ethanol elevation in rats: involvement of inhibition of gastric emptying and increase in gastric juice secretion", ALCOHOL ALCOHOL., vol. 37, no. 2, March 2002 (2002-03-01), pages 121 - 7 1; MEERUM TERWOGT JM ET AL.: "Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel", ANTICANCER DRUGS, vol. 12, no. 4, April 2001 (2001-04-01), pages 315 - 23, XP008124180, DOI: doi:10.1097/00001813-200104000-00003 1; MEERUM TERWOGT, J. M. ET AL.: "Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel", ANTICANCER DRUGS, vol. 12, 2001, pages 315 - 323, XP008124180, DOI: doi:10.1097/00001813-200104000-00003 1; MERCADO-GOMEZ O; FERRERA P; ARIAS C: "Histopathologic changes induced by the microtubule-stabilizing agent Taxol in the rat hippocampus in vivo", J NEUROSCI RES, vol. 78, no. 4, 2004, pages 553 - 62, XP009050947, DOI: doi:10.1002/jnr.20264 1; MIGLIETTA, A. ET AL.: "Microtubule- interfering activity of parthenolide", CHEM BIOL INTERACT, vol. 149, 2004, pages 165 - 173, XP004610285, DOI: doi:10.1016/j.cbi.2004.07.005 1; MINGUEZ, J. M ET AL., MOL. CANCER THER., vol. 1, 2002, pages 1305 - 1313 1; MINGUEZ, J. M. ET AL., BIOORG. MED. CHEM., vol. 11, 2003, pages 3335 - 3357 1; MOOBERRY, S. L. ET AL.: "Laulimalide and isolaulimalide, new paclitaxel-like microtubule- stabilizing agents.", CANCER RES, vol. 59, 1999, pages 653 - 660 1; MOOBERRY, S. L.; STRATMAN, K.; MOORE, R. E.: "Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect.", CANCER LETT, vol. 96, 1995, pages 261 - 266 1; MOOBERRY, S. L; STRATMAN, K.; MOORE, R. E.: "Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect", CANCER LETT, vol. 96, 1995, pages 261 - 266 1; MOON L. D., NAT. NEUROSCIENCE, vol. 4, 2001, pages 465 - 466 1; MULTANI, A. S. ET AL.: "Paclitaxel and water-soluble poly (L-glutamic acid)- paclitaxel, induce direct chromosomal abnormalities and cell death in a murine metastatic melanoma cell line", ANTICANCER RES, vol. 17, 1997, pages 4269 - 4274, XP001023469 1; NAKAMURA, M. ET AL.: "Nordihydroguaiaretic acid, of a new family of microtubule- stabilizing agents, shows effects differentiated from paclitaxel", BIOSCI BIOTECHNOL BIOCHEM, vol. 67, 2003, pages 151 - 157 1; NEUMANN S. ET AL., NEURON, vol. 34, 2002, pages 885 - 893 1; NEUMANN S.; WOOLF C. J., NEURON, vol. 23, 1999, pages 83 - 91 1; NICOLAOU, K. C. ET AL.: "Design, synthesis and biological activity of protaxols", NATURE, vol. 364, 1993, pages 464 - 466, XP002003374, DOI: doi:10.1038/364464a0 1; NICOLETTI, M. I. ET AL.: "IDN5109, a taxane with oral bioavailability and potent antitumor activity", CANCER RES, vol. 60, 2000, pages 842 - 846 1; NIKULINA, E., PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 8786 - 8790 1; O'REILLY , T. ET AL.: "Patupilone (epothilone B, EPO 906 ) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma", CANCER CHEMOTHER PHARMACOL, vol. 55, 2005, pages 307 - 317, XP019334131, DOI: doi:10.1007/s00280-004-0913-z 1; OJIMA, I. ET AL.: "A common pharmacophore for cytotoxic natural products that stabilize microtubules", PROC NATL ACAD SCI U S A, vol. 96, 1999, pages 4256 - 4261, XP000991093, DOI: doi:10.1073/pnas.96.8.4256 1; OJIMA, I. ET AL.: "Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells", J MED CHEM, vol. 39, 1996, pages 3889 - 3896 1; OLDHAM, E. A. ET AL.: "Comparison of action of paclitaxel and poly(L-glutamic acid)-paclitaxel conjugate in human breast cancer cells", INT J ONCOL, vol. 16, 2000, pages 125 - 132 1; OLSEN DB ET AL.: "A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties", ANTIMICROB AGENTS CHEMOTHER, vol. 48, no. 10, October 2004 (2004-10-01), pages 3944 - 53 1; PATERSON, I.; DELGADO, O., TETRAHEDRON LETT., vol. 44, 2003, pages 8877 - 8882 1; PATERSON, I.; FLORENCE, G. J., TETRAHEDRON LETT., vol. 41, 2000, pages 6935 - 6939 1; PAXINOS G.; WATSON C.: "THE RAT BRAIN IN STEREOTAXIC COORDINATES", 1982, ACADEMIC PRESS 1; PEARSE, D. D., NAT. MED., vol. 10, 2004, pages 610 - 616 1; PEREZ-ESPEJO MA ET AL.: "The effects of taxol, methylprednisolone, and 4-aminopyridine in compressive spinal cord injury: a qualitative experimental study", SURG NEUROL, vol. 46, no. 4, 1996, pages 350 - 7, XP002337223, DOI: doi:10.1016/S0090-3019(96)00200-5 1; PETRANGOLINI G ET AL.: "Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft.", BR J CANCER., vol. 90, no. 7, 5 April 2004 (2004-04-05), pages 1464 - 8, XP055134305, DOI: doi:10.1038/sj.bjc.6601730 1; POLIZZI, D. ET AL.: "A novel taxane with improved tolerability and therapeutic activity in a panel of human tumor xenografts.", CANCER RES, vol. 59, 1999, pages 1036 - 1040, XP002611544 1; QIU J.; FILBIN M.T, GLIA, vol. 29, 2000, pages 166 - 174 1; RAMASWAMY, M. ET AL.: "Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers", J PHARM SCI, vol. 86, 1997, pages 460 - 464, XP000683467, DOI: doi:10.1021/js960333n 1; RAO, S. ET AL.: "3'-(p-azidobenzamido)taxol photolabels the N- terminal 31 amino acids of beta-tubulin", J BIOL CHEM, vol. 269, 1994, pages 3132 - 3134 1; RAO, S. ET AL.: "Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxo", J BIOL CHEM, vol. 274, 1999, pages 37990 - 37994 1; RAO, S. ET AL.: "Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol", J BIOL CHEM, vol. 274, 1999, pages 37990 - 37994 1; RAO, S. ET AL.: "Characterization of the taxol binding site on the microtubule. 2-(m- Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231 ) of beta- tubulin", J BIOL CHEM, vol. 270, 1995, pages 20235 - 20238, XP002143078, DOI: doi:10.1074/jbc.270.34.20011 1; REINER A. ET AL., J NEUROSCI METHODS, vol. 103, 2000, pages 23 - 37 1; RINGEL, I.; HORWITZ, S. B.: "Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol", J NATL CANCER INST, vol. 83, 1991, pages 288 - 291 1; RODRIGUEZ, O. C.: "Conserved microtubule-actin interactions in cell movement and morphogenesis", NAT CELL BIOL, vol. 5, 2003, pages 599 - 609 1; ROSE WC ET AL.: "Preclinical antitumor activity of water-soluble paclitaxel derivatives.", CANCER CHEMOTHER PHARMACOL., vol. 39, no. 6, 1997, pages 486 - 92 1; ROSE WC ET AL.: "Preclinical pharmacology of BMS-275183, an orally active taxane.", CLIN CANCER RES., vol. 7, no. 7, July 2001 (2001-07-01), pages 2016 - 21 1; ROSE, W. C. ET AL.: "Preclinical antitumor activity of water-soluble paclitaxel derivatives.", CANCER CHEMOTHER PHARMACOL, vol. 39, 1997, pages 486 - 492 1; ROSE, W. C. ET AL.: "Preclinical oral antitumor activity of BMS-185660, a paclitaxel derivative.", CANCER CHEMOTHER PHARMACOL, vol. 46, 2000, pages 246 - 250 1; ROSE, W. C. ET AL.: "Preclinical pharmacology of BMS-275183, an orally active taxane", CLIN CANCER RES, vol. 7, 2001, pages 2016 - 2021 1; ROSE, W. C.; FAIRCHILD, C.; LEE, F. Y.: "Preclinical antitumor activity of two novel taxanes.", CANCER CHEMOTHER PHARMACOL, vol. 47, 2001, pages 97 - 105 1; SAMPATH, D. ET AL.: "MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo", MOL CANCER THER, vol. 2, 2003, pages 873 - 884, XP002987790 1; SAMPATH, D. ET AL.: "MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.", MOL CANCER THER, vol. 2, 2003, pages 873 - 884, XP002987790 1; SANDVIG A. ET AL., GLIA, vol. 46, 2004, pages 225 - 251 1; SARUHASHI Y.; YOUNG W.; PERKINS R., EXP NEUROL., vol. 139, 1996, pages 203 - 213 1; SASSE, R.; GULL, K.: "Tubulin post-translational modifications and the construction of microtubular organelles in Trypanosoma brucei", J CELL SCI, vol. 90, no. PT 4, 1988, pages 577 - 89 1; SATO B ET AL.: "A new antimitotic substance, FR 182877 . I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities", J ANTIBIOT (TOKYO, vol. 53, no. 2, February 2000 (2000-02-01), pages 123 - 30 1; SATO, B ET AL.: "A new antimitotic substance, FR 182877 . I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.", J ANTIBIOT (TOKYO, vol. 53, 2000, pages 123 - 130 1; SATO, B ET AL.: "A new antimitotic substance, FR 182877 . II. The mechanism of action", J ANTIBIOT (TOKYO, vol. 53, 2000, pages 204 - 206 1; SATO, B. ET AL.: "A new antimitotic substance, FR 182877 . II. The mechanism of action.", J ANTIBIOT (TOKYO, vol. 53, 2000, pages 204 - 206 1; SCHIFF, P. B.; FANT, J.; HORWITZ, S. B.: "Promotion of microtubule assembly in vitro by taxol", NATURE, vol. 277, 1979, pages 665 - 667, XP001007871, DOI: doi:10.1038/277665a0 1; SCHIFF, P. B.; FANT, J.; HORWITZ, S. B.: "Promotion of microtubule assembly in vitro by taxol.", NATURE, vol. 277, 1979, pages 665 - 7, XP001007871, DOI: doi:10.1038/277665a0 1; SCHIFF, P. B.; HORWITZ, S. B.: "Taxol stabilizes microtubules in mouse fibroblast cells", PROC NATL ACAD SCI U S A, vol. 77, 1980, pages 1561 - 1565, XP001007666, DOI: doi:10.1073/pnas.77.3.1561 1; SCHIFF, P. B.; HORWITZ, S. B.: "Taxol stabilizes microtubules in mouse fibroblast cells", PROC NATL ACAD SCI U S A, vol. 77, 1980, pages 1561 - 5, XP001007666, DOI: doi:10.1073/pnas.77.3.1561 1; SCHLIWA, M.; HONER, B: "Microtubules, centrosomes and intermediate filaments in directed cell movement", TRENDS CELL BIOL, vol. 3, 1993, pages 377 - 80, XP023554041, DOI: doi:10.1016/0962-8924(93)90086-G 1; SCHMIDT B. J.; JORDAN L. M., BRAIN RES BULL, vol. 53, 2000, pages 689 - 710 1; SESSA C ET AL.: "A clinical and pharmacokinetic (PK) phase I study of RPR 109881A, a new taxoid administerd as a three hour intravenous infusion to patients with advanced solid tumors.", PROCEEDINGS OF ASCO, vol. 17, 1998, pages 728 1; SHIN, Y. ET AL., ORG. LETT., vol. 4, 2002, pages 4443 - 4446 1; SHINTANI, Y.; TANAKA, T.; NOZAKI, Y.: "GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol", CANCER CHEMOTHER PHARMACOL, vol. 40, 1997, pages 513 - 520 1; SHIONOYA, M. ET AL.: "DJ- 927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo", CANCER SCI, vol. 94, 2003, pages 459 - 466 1; SILVER J.; MILLER J. H., NAT REV NEUROSCI, vol. 5, 2004, pages 146 - 156 1; SMART, C. R. ET AL.: "An interesting observation on nordihydroguaiaretic acid (NSC- 4291; NDGA) and a patient with malignant melanoma--a preliminary report", CANCER CHEMOTHER REP, vol. 53, 1969, pages 147 - 151 1; SMITH DS; SKENE JH: "A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth", J NEUROSCI, vol. 17, no. 2, 1997, pages 646 - 58 1; SMITH K. J.; BENNETT B. J., J ANAT, vol. 153, 1987, pages 203 - 215 1; SMITH, A.B., 3RD: "Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide", ORG LETT, vol. 7, no. 2, 2005, pages 311 - 4 1; SMITH, A.B.: "Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide.", ORG LETT, vol. 7, no. 2, 2005, pages 315 - 8 1; SMITH, C. L.: "Cytoskeletal movements and substrate interactions during initiation of neurite outgrowth by sympathetic neurons in vitro", J NEUROSCI, vol. 14, 1994, pages 384 - 398, XP009015419 1; STACHEL, S. J. ET AL.: "On the total synthesis and preliminary biological evaluations of 15(R) and 15(S) aza-dEpoB: a Mitsunobu inversion at C15 in pre-epothilone fragments", ORG LETT, vol. 2, 2000, pages 1637 - 1639 1; SYED, S. K. ET AL.: "Phase I and Pharmacokinetics (PK) of DJ-927, an oral taxane, in patients (Pts) with advanced cancers", J CLIN ONCOL ( MEETING ABSTRACTS, vol. 22, 2004, pages 2028 1; TAKEDA Y ET AL.: "New highly active taxoids from 9beta- dihydrobaccatin-9,10-acetals. Part 3", BIOORG MED CHEM LETT., vol. 13, no. 2, 20 January 2003 (2003-01-20), pages 185 - 90 1; TAKEDA, Y. ET AL.: "New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 3", BIOORG MED CHEM LETT, vol. 13, 2003, pages 185 - 190 1; TARABOLETTI, G. ET AL.: "Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative", CLIN CANCER RES, vol. 8, 2002, pages 1182 - 1188, XP002395173 1; TARRANT, J. G. ET AL.: "Synthesis and biological activity of macrocyclic taxane analogues", BIOORG MED CHEM LETT, vol. 14, 2004, pages 2555 - 2558, XP004841238, DOI: doi:10.1016/j.bmcl.2004.02.086 1; TER HAAR, E. ET AL.: "Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.", BIOCHEMISTRY, vol. 35, 1996, pages 243 - 250, XP002154629, DOI: doi:10.1021/bi9515127 1; TINLEY, T. L. ET AL.: "Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity", CANCER RES, vol. 63, 2003, pages 3211 - 3220 1; TODD, R. ET AL.: "Phase I and Pharmalocological Study of CT-2103, a Poly(L-glutamic Acid)-Paclitaxel Conjugate", PROC AM SOC CLIN ONCOL, vol. 20, 2001, pages 111A 1; TRACEY D.: "IN THE RAT NERVOUS SYSTEM", 1995, ACADEMIC PRESS, article "Ascending and descending pathways in the spinal cord", pages: 67 - 80 1; UYAR, D. ET AL.: "Apoptotic pathways of epothilone BMS 310705", GYNECOL ONCOL, vol. 91, 2003, pages 173 - 178 1; WANI, M. C. ET AL.: "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia", J AM CHEM SOC, vol. 93, 1971, pages 2325 - 2327, XP002037887, DOI: doi:10.1021/ja00738a045 1; WEB STER, D. R. ET AL.: "Differential turnover of tyrosinated and detyrosinated microtubules", PROC NATL ACAD SCI U S A, vol. 84, 1987, pages 9040 - 4 1; WEHLAND, J.; WEB ER, K.: "Turnover of the carboxy-terminal tyrosine of alpha- tubulin and means of reaching elevated levels of detyrosination in living cells", J CELL SCI, vol. 88, no. PT 2, 1987, pages 185 - 203, XP002061472 1; WETTSCHURECK N.; OFFERMANNS S., J MOL MED., vol. 80, 2002, pages 629 - 638 1; WILDE C.; VOGELSGESANG M.; AKTORIES K., BIOCHEMISTRY, vol. 42, 2003, pages 9694 - 9702 1; WINTON MJ ET AL., J BIOL CHEM., vol. 277, 2002, pages 32820 - 32829 1; WOLFF, A. C. ET AL.: "Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile", CLIN CANCER RES, vol. 9, 2003, pages 3589 - 3597 1; WU, J. H.; BATIST, G.; ZAMIR, L. O.: "Identification of a novel steroid derivative, NSC12983, as a paclitaxel-like tubulin assembly promoter by 3-D virtual screening", ANTICANCER DRUG DES, vol. 16, 2001, pages 129 - 133 1; WU, J. H; BATIST, G.; ZAMIR, L. O.: "Identification of a novel steroid derivative, NSC12983, as a paclitaxel-like tubulin assembly promoter by 3-D virtual screening", ANTICANCER DRUG DES, vol. 16, 2001, pages 129 - 133 1; YARM, F; SAGOT, I.; PELLMAN, D.: "The social life of actin and microtubules: interaction versus cooperation", CURR OPIN MICROBIOL, vol. 4, 2001, pages 696 - 702 1; ZHANG X ET AL.: "Anti-tumor efficacy and biodistribution of intravenous polymeric micellar paclitaxel", ANTICANCER DRUGS, vol. B, no. 7, August 1997 (1997-08-01), pages 696 - 701, XP008155021, DOI: doi:10.1097/00001813-199708000-00008 1; ZHANG, X. ET AL.: "An investigation of the antitumour activity and biodistribution of polymeric micellar paclitaxel", CANCER CHEMOTHER PHARMACOL, vol. 40, 1997, pages 81 - 86, XP000911965, DOI: doi:10.1007/s002800050630 1; ZHANG, X. ET AL.: "Anti-tumor efficacy and biodistribution of intravenous polymeric micellar paclitaxel", ANTICANCER DRUGS, vol. 8, 1997, pages 696 - 701, XP008155021, DOI: doi:10.1097/00001813-199708000-00008 1
|