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Dokument EP000001700596A1 (Seiten: 54)

Bibliografische Daten Dokument EP000001700596A1 (Seiten: 54)
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54 Titel TI [DE] Verwendung von Mikrotubuli stabilisierenden Verbindungen zur Behandlung von axonalen Läsionen im ZNS
[EN] Use of microtubule stabilizing compounds for the treatment of lesions of CNS axons
[FR] Utilisation de composés stabilisant les microtubules pour le traitement des lesions axonales du SNC
71/73 Anmelder/Inhaber PA MAX PLANCK GESELLSCHAFT, DE
72 Erfinder IN BRADKE FRANK, DE ; WITTE HARALD, DE
22/96 Anmeldedatum AD 09.03.2005
21 Anmeldenummer AN 05005151
Anmeldeland AC EP
Veröffentlichungsdatum PUB 13.09.2006
33
31
32
Priorität PRC
PRN
PRD


51 IPC-Hauptklasse ICM A61K 31/00 (2006.01)
51 IPC-Nebenklasse ICS A61K 31/337 (2006.01)
A61P 25/00 (2006.01)
IPC-Zusatzklasse ICA
IPC-Indexklasse ICI
Gemeinsame Patentklassifikation CPC A61K 31/337
A61K 31/427
A61K 45/06
A61P 25/00
MCD-Hauptklasse MCM A61K 31/00 (2006.01)
MCD-Nebenklasse MCS A61K 31/337 (2006.01)
A61P 25/00 (2006.01)
MCD-Zusatzklasse MCA
57 Zusammenfassung AB [EN] The present invention provides a use of one or more microtubule stabilizing compounds for the preparation of a pharmaceutical composition for the treatment of lesions of CNS axons wherein the pharmaceutical composition is administered locally directly into the lesion or immediately adjacent thereto, whereby the one or more compound(s) is/are selected from the group consisting of taxanes, epothilones, laulimalides, sesquiterpene lactones, sarcodictyins, diterpenoids, peloruside A, discodermolide, dicoumarol, ferulenol, NSC12983, taccalonolide A, taccalonolide E, Rhazinilam, nordihydroguaiaretic acid (NDGA), GS-164, borneol esters, Synstab A, Tubercidin and FR182877 (WS9885B). Furthermore, the invention provides a method for the treatment of lesions of CNS axons the method comprising the step of administering to a patient in the need thereof a pharmaceutical composition comprising (i) one or more microtubule stabilizing compounds selected from the group consisting of taxanes, epothilones, laulimalides, sesquiterpene lactones, sarcodictyins, diterpenoids, peloruside A, discodermolide, dicoumarol, ferulenol, NSC12983, taccalonolide A, taccalonolide E, Rhazinilam, nordihydroguaiaretic acid (NDGA), GS-164, borneol esters, Synstab A, Tubercidin and FR182877 (WS9885B) and, optionally, (ii) further comprising suitable formulations of carrier, stabilizers and/or excipients, wherein the pharmaceutical composition is administered locally directly into the lesion or immediately adjacent thereto.
56 Entgegengehaltene Patentdokumente/Zitate,
in Recherche ermittelt
CT WO001998024427A2
WO002005014783A2
56 Entgegengehaltene Patentdokumente/Zitate,
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CT
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